| Literature DB >> 19660179 |
Bruno Solano de Freitas Souza1, Renata Campos Nogueira, Sheilla Andrade de Oliveira, Luiz Antonio Rodrigues de Freitas, Luiz Guilherme Costa Lyra, Ricardo Ribeiro dos Santos, Andre Castro Lyra, Milena Botelho Pereira Soares.
Abstract
Liver failure is one of the main causes of death worldwide and is a growing health problem. Since the discovery of stem cell populations capable of differentiating into specialized cell types, including hepatocytes, the possibility of their utilization in the regeneration of the damaged liver has been a focus of intense investigation. A variety of cell types were tested both in vitro and in vivo, but the definition of a more suitable cell preparation for therapeutic use in each type of liver lesions is yet to be determined. Here we review the protocols described for differentiation of stem cells into hepatocytes, the results of cell therapy in animal models of liver diseases, as well as the available data of the clinical trials in patients with advanced chronic liver disease.Entities:
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Year: 2009 PMID： 19660179 DOI： 10.3727/096368909X470522
Source DB: PubMed Journal: Cell Transplant ISSN： 0963-6897 Impact factor: 4.064