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Literature DB >> 19656977

Atypical Aspergillus flavus isolates associated with chronic azole therapy.

Mary E Brandt¹, Lalitha Gade, Cindy B McCloskey, S Arunmozhi Balajee.

Abstract

A case of chronic sinus disease due to morphologically atypical Aspergillus flavus is described. Multiple fungal isolates sporulated poorly or not at all, displaying unusual color and microscopic morphology, including the absence of typical vesicles and phialides, which caused the isolates to resemble several other fungal genera superficially. The patient received multiple antifungal therapies over at least 10 years with various azole drugs, including voriconazole, itraconazole, and posaconazole. We speculate that this lengthy exposure to azole antifungal drugs may have caused or promoted the atypical morphology seen in these isolates.

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Year: 2009 PMID： 19656977 PMCID： PMC2756908 DOI： 10.1128/JCM.00671-09

Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948

11 in total

1. Chronic invasive aspergillosis of the paranasal sinuses in immunocompetent hosts from Saudi Arabia.

Authors: A A Alrajhi; M Enani; Z Mahasin; K Al-Omran
Journal: Am J Trop Med Hyg Date: 2001-07 Impact factor: 2.345

Review 2. Relationship between secondary metabolism and fungal development.

Authors: Ana M Calvo; Richard A Wilson; Jin Woo Bok; Nancy P Keller
Journal: Microbiol Mol Biol Rev Date: 2002-09 Impact factor: 11.056

3. Discovering potential pathogens among fungi identified as nonsporulating molds.

Authors: June I Pounder; Keith E Simmon; Claudia A Barton; Sheri L Hohmann; Mary E Brandt; Cathy A Petti
Journal: J Clin Microbiol Date: 2006-11-29 Impact factor: 5.948

4. Newer emerging pathogens of ocular non-sporulating molds (NSM) identified by polymerase chain reaction (PCR)-based DNA sequencing technique targeting internal transcribed spacer (ITS) region.

Authors: R Bagyalakshmi; K L Therese; S Prasanna; H N Madhavan
Journal: Curr Eye Res Date: 2008-02 Impact factor: 2.424

5. Upstream and downstream regulation of asexual development in Aspergillus fumigatus.

Authors: Jae-Hyung Mah; Jae-Hyuk Yu
Journal: Eukaryot Cell Date: 2006-10

6. Semi-invasive allergic aspergillosis of the paranasal sinuses.

Authors: M F Oyarzabal; E B Chevretton; R J Hay
Journal: J Laryngol Otol Date: 2000-04 Impact factor: 1.469

7. Identification of species in Aspergillus section Flavi based on sequencing of the mitochondrial cytochrome b gene.

Authors: L Wang; K Yokoyama; H Takahasi; N Kase; Y Hanya; K Yashiro; M Miyaji; K Nishimura
Journal: Int J Food Microbiol Date: 2001-12-04 Impact factor: 5.277

8. Novel effect of voriconazole on conidiation of Aspergillus species.

Authors: Neeraja L Varanasi; Inthumathi Baskaran; George J Alangaden; Pranatharthi H Chandrasekar; Elias K Manavathu
Journal: Int J Antimicrob Agents Date: 2004-01 Impact factor: 5.283

9. Nonsporulating clinical isolate identified as Petromyces alliaceus (anamorph Aspergillus alliaceus) by morphological and sequence-based methods.

Authors: S Arunmozhi Balajee; Mark D Lindsley; Naureen Iqbal; James Ito; Peter G Pappas; Mary E Brandt
Journal: J Clin Microbiol Date: 2007-05-30 Impact factor: 5.948

10. Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus.

Authors: Kwame Twumasi-Boateng; Yan Yu; Dan Chen; Fabrice N Gravelat; William C Nierman; Donald C Sheppard
Journal: Eukaryot Cell Date: 2008-11-21

3 in total