BACKGROUND: Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known. OBJECTIVE: To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures. DESIGN: A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial. MEASUREMENTS: Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH <or=65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH. RESULTS: Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total (P = 0.02), truncal (P = 0.03) and extremity (P = 0.03) fat mass, while 25-OH D was inversely related to truncal fat mass (P = 0.02). Total fat mass in groups 1-3, respectively, was 30.0, 34.0 and 37.4 kg (P = 0.008); truncal fat mass was 13.4, 15.9 and 17.6 kg (P = 0.006) and extremity fat mass was 15.8, 16.9 and 19.7 kg (P = 0.02). Lean mass did not differ across the three groups. CONCLUSIONS: Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.
BACKGROUND:Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known. OBJECTIVE: To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures. DESIGN: A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial. MEASUREMENTS: Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH <or=65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH. RESULTS: Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total (P = 0.02), truncal (P = 0.03) and extremity (P = 0.03) fat mass, while 25-OH D was inversely related to truncal fat mass (P = 0.02). Total fat mass in groups 1-3, respectively, was 30.0, 34.0 and 37.4 kg (P = 0.008); truncal fat mass was 13.4, 15.9 and 17.6 kg (P = 0.006) and extremity fat mass was 15.8, 16.9 and 19.7 kg (P = 0.02). Lean mass did not differ across the three groups. CONCLUSIONS: Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.
Authors: B E Ainsworth; W L Haskell; M C Whitt; M L Irwin; A M Swartz; S J Strath; W L O'Brien; D R Bassett; K H Schmitz; P O Emplaincourt; D R Jacobs; A S Leon Journal: Med Sci Sports Exerc Date: 2000-09 Impact factor: 5.411
Authors: Cheryl L Rock; Jennifer A Emond; Shirley W Flatt; Dennis D Heath; Njeri Karanja; Bilge Pakiz; Nancy E Sherwood; Cynthia A Thomson Journal: Obesity (Silver Spring) Date: 2012-03-08 Impact factor: 5.002
Authors: Paulette D Chandler; Lu Wang; Xi Zhang; Howard D Sesso; Manickavasagar V Moorthy; Obiageli Obi; Joshua Lewis; Richard L Prince; Jacqueline S Danik; JoAnn E Manson; Meryl S LeBoff; Yiqing Song Journal: Nutr Rev Date: 2015-07-14 Impact factor: 7.110
Authors: Jorge N Artaza; Sandra Contreras; Leah A Garcia; Rajnish Mehrotra; Gary Gibbons; Ralph Shohet; David Martins; Keith C Norris Journal: J Health Care Poor Underserved Date: 2011
Authors: Veronika Fedirko; Elio Riboli; H Bas Bueno-de-Mesquita; Sabina Rinaldi; Tobias Pischon; Teresa Norat; Eugène H J M Jansen; Fränzel J B van Duijnhoven; Anne Tjønneland; Anja Olsen; Kim Overvad; Marie-Christine Boutron-Ruault; Françoise Clavel-Chapelon; Pierre Engel; Rudolf Kaaks; Birgit Teucher; Heiner Boeing; Brian Buijsse; Antonia Trichopoulou; Dimitrios Trichopoulos; Pagona Lagiou; Sabina Sieri; Paolo Vineis; Salvatore Panico; Domenico Palli; Rosario Tumino; Carla H van Gils; Petra H M Peeters; Maria-Dolores Chirlaque; Aurelio Barricarte Gurrea; Laudina Rodríguez; Esther Molina-Montes; Miren Dorronsoro; Catalina Bonet; Richard Palmqvist; Göran Hallmans; Timothy J Key; Konstantinos K Tsilidis; Kay-Tee Khaw; Isabelle Romieu; Kurt Straif; Petra A Wark; Dora Romaguera; Mazda Jenab Journal: Cancer Epidemiol Biomarkers Prev Date: 2011-03-04 Impact factor: 4.254