| Literature DB >> 19655733 |
Michael E Jung1, Jesus Cordova, Masayuki Murakami.
Abstract
The total synthesis of the diterpene kellermanoldione 1 is reported. Stepwise [4 + 2] cycloaddition of the ketal diene 8 and the allenoate 3 afforded the exo adduct 10x as the major product. It was converted into 1 via six steps, among them a key nonconjugative hydrolysis of a gamma-methylene silyl enol ether.Entities:
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Year: 2009 PMID： 19655733 DOI： 10.1021/ol901455q
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005