AIMS: Heart failure (HF) with normal or preserved left ventricular (LV) ejection fraction (HFPEF) has been reported to be associated with similar outcome as HF with reduced EF (HFREF) in registry-based and epidemiological analyses, but many of these studies excluded patients who did not have EF measurements. Conversely, prior prospective studies have reported better outcome for patients with HFPEF. We performed a meta-analysis of prospective observational studies comparing all-cause mortality in patients with HFREF and HFPEF. METHODS AND RESULTS: We searched several online databases for studies comparing outcome in HFREF and HFPEF, published before 2007. INCLUSION CRITERIA: prospective, clinical HF, near complete EF data, and mortality outcome. Review Manager version 4.2.3 software was used for the analysis. Overall, 24 501 patients [9299 deaths (38%)] from 17 studies are included. Average follow-up was 47 months; the HFPEF group was older (69 vs. 66 years) and more likely to be female (44% vs. 26%). Of the 7688 patients with HFPEF 2468 died (32.1%), compared with 6831 of the 16 813 patients with HFREF (40.6%): odds ratio 0.51 (95% CI: 0.48, 0.55). CONCLUSION: This literature-based meta-analysis demonstrates that mortality among patients with HFPEF was half that observed in those with HFREF, in contrast to previous reports suggesting that mortality may be similar between both groups.
AIMS: Heart failure (HF) with normal or preserved left ventricular (LV) ejection fraction (HFPEF) has been reported to be associated with similar outcome as HF with reduced EF (HFREF) in registry-based and epidemiological analyses, but many of these studies excluded patients who did not have EF measurements. Conversely, prior prospective studies have reported better outcome for patients with HFPEF. We performed a meta-analysis of prospective observational studies comparing all-cause mortality in patients with HFREF and HFPEF. METHODS AND RESULTS: We searched several online databases for studies comparing outcome in HFREF and HFPEF, published before 2007. INCLUSION CRITERIA: prospective, clinical HF, near complete EF data, and mortality outcome. Review Manager version 4.2.3 software was used for the analysis. Overall, 24 501 patients [9299 deaths (38%)] from 17 studies are included. Average follow-up was 47 months; the HFPEF group was older (69 vs. 66 years) and more likely to be female (44% vs. 26%). Of the 7688 patients with HFPEF 2468 died (32.1%), compared with 6831 of the 16 813 patients with HFREF (40.6%): odds ratio 0.51 (95% CI: 0.48, 0.55). CONCLUSION: This literature-based meta-analysis demonstrates that mortality among patients with HFPEF was half that observed in those with HFREF, in contrast to previous reports suggesting that mortality may be similar between both groups.
Authors: Oliver Riedel; C Ohlmeier; D Enders; A Elsässer; D Vizcaya; A Michel; S Eberhard; N Schlothauer; J Berg; E Garbe Journal: Clin Res Cardiol Date: 2018-02-05 Impact factor: 5.460
Authors: Carolyn S P Lam; Asya Lyass; Elisabeth Kraigher-Krainer; Joseph M Massaro; Douglas S Lee; Jennifer E Ho; Daniel Levy; Margaret M Redfield; Burkert M Pieske; Emelia J Benjamin; Ramachandran S Vasan Journal: Circulation Date: 2011-06-13 Impact factor: 29.690
Authors: Ramachandran S Vasan; Vanessa Xanthakis; Asya Lyass; Charlotte Andersson; Connie Tsao; Susan Cheng; Jayashri Aragam; Emelia J Benjamin; Martin G Larson Journal: JACC Cardiovasc Imaging Date: 2017-10-05
Authors: Michael R Bristow; David P Kao; Khadijah K Breathett; Natasha L Altman; John Gorcsan; Edward A Gill; Brian D Lowes; Edward M Gilbert; Robert A Quaife; Douglas L Mann Journal: JACC Heart Fail Date: 2017-11 Impact factor: 12.035
Authors: Pedro Almeida; João Rodrigues; Patricia Lourenço; Maria Julia Maciel; Paulo Bettencourt Journal: Clin Cardiol Date: 2012-08-09 Impact factor: 2.882