Literature DB >> 19653069

Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering.

Paola Fabbri1, Federica Bondioli, Massimo Messori, Cristina Bartoli, Dinuccio Dinucci, Federica Chiellini.   

Abstract

Polycaprolactone/hydroxyapatite (PCL/HA) composites were prepared by in situ generation of HA in the polymer solution starting from the precursors calcium nitrate tetrahydrate and ammonium dihydrogen phosphate via sol-gel process. Highly interconnected porosity was achieved by means of the salt-leaching technique using a mixture of sodium chloride and sodium bicarbonate as porogens. Structure and morphology of the PCL/HA composites were investigated by scanning electron microscopy, and mechanical properties were determined by means of tensile and compression tests. The possibility to employ the developed composites as scaffolds for bone tissue regeneration was assessed by cytotoxicity test of the PCL/HA composites extracts and cell adhesion and proliferation in vitro studies.

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Year:  2009        PMID： 19653069     DOI： 10.1007/s10856-009-3839-5

Source DB:  PubMed          Journal:  J Mater Sci Mater Med        ISSN： 0957-4530            Impact factor:   3.896


  16 in total

1.  In vitro and in vivo degradation of non-woven materials made of poly(epsilon-caprolactone) nanofibers prepared by electrospinning under different conditions.

Authors:  N Bölgen; Y Z Menceloğlu; K Acatay; I Vargel; E Pişkin
Journal:  J Biomater Sci Polym Ed       Date:  2005       Impact factor: 3.517

2.  Bioactivity in in situ hydroxyapatite-polycaprolactone composites.

Authors:  Devendra Verma; Kalpana Katti; Dinesh Katti
Journal:  J Biomed Mater Res A       Date:  2006-09-15       Impact factor: 4.396

3.  Poly-epsilon-caprolactone/hydroxyapatite composites for bone regeneration: in vitro characterization and human osteoblast response.

Authors:  F Causa; P A Netti; L Ambrosio; G Ciapetti; N Baldini; S Pagani; D Martini; A Giunti
Journal:  J Biomed Mater Res A       Date:  2006-01       Impact factor: 4.396

4.  Ring-opening polymerization of lactones in the presence of hydroxyapatite.

Authors:  E Helwig; B Sandner; U Gopp; F Vogt; S Wartewig; S Henning
Journal:  Biomaterials       Date:  2001-10       Impact factor: 12.479

5.  In-situ preparation of poly(propylene fumarate)--hydroxyapatite composite.

Authors:  Dorna Hakimimehr; Dean-Mo Liu; Tom Troczynski
Journal:  Biomaterials       Date:  2005-12       Impact factor: 12.479

6.  Sol-gel synthesis, structure and bioactivity of polycaprolactone/CaO . SiO2 hybrid material.

Authors:  M Catauro; M G Raucci; F De Gaetano; A Buri; A Marotta; L Ambrosio
Journal:  J Mater Sci Mater Med       Date:  2004-09       Impact factor: 3.896

7.  Biomedical nanocomposites of hydroxyapatite/polycaprolactone obtained by surfactant mediation.

Authors:  Hae-Won Kim
Journal:  J Biomed Mater Res A       Date:  2007-10       Impact factor: 4.396

8.  Effect of porosity and pore size on microstructures and mechanical properties of poly-epsilon-caprolactone- hydroxyapatite composites.

Authors:  Haiying Yu; Howard W Matthew; Paul H Wooley; Shang-You Yang
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2008-08       Impact factor: 3.368

9.  Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro.

Authors:  Lauren Shor; Selçuk Güçeri; Xuejun Wen; Milind Gandhi; Wei Sun
Journal:  Biomaterials       Date:  2007-09-19       Impact factor: 12.479

10.  Osteoblastic phenotype expression of MC3T3-E1 cultured on electrospun polycaprolactone fiber mats filled with hydroxyapatite nanoparticles.

Authors:  Patcharaporn Wutticharoenmongkol; Prasit Pavasant; Pitt Supaphol
Journal:  Biomacromolecules       Date:  2007-07-27       Impact factor: 6.988
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  20 in total

1.  In vitro and in vivo evaluation of rotary-jet-spun poly(ɛ-caprolactone) with high loading of nano-hydroxyapatite.

Authors:  Telmo M Andrade; Daphne C R Mello; Conceição M V Elias; Julia M A Abdala; Edmundo Silva; Luana M R Vasconcellos; Carla R Tim; Fernanda R Marciano; Anderson O Lobo
Journal:  J Mater Sci Mater Med       Date:  2019-01-28       Impact factor: 3.896

Review 2.  Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration.

Authors:  Angshuman Bharadwaz; Ambalangodage C Jayasuriya
Journal:  Mater Sci Eng C Mater Biol Appl       Date:  2020-01-29       Impact factor: 7.328

Review 3.  Polycaprolactone as biomaterial for bone scaffolds: Review of literature.

Authors:  Ruby Dwivedi; Sumit Kumar; Rahul Pandey; Aman Mahajan; Deepti Nandana; Dhirendra S Katti; Divya Mehrotra
Journal:  J Oral Biol Craniofac Res       Date:  2019-11-05

4.  HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties.

Authors:  Mehran Mehrabanian; Mojtaba Nasr-Esfahani
Journal:  Int J Nanomedicine       Date:  2011-08-11

5.  Transcriptome analysis of MSC and MSC-derived osteoblasts on Resomer® LT706 and PCL: impact of biomaterial substrate on osteogenic differentiation.

Authors:  Sabine Neuss; Bernd Denecke; Lin Gan; Qiong Lin; Manfred Bovi; Christian Apel; Michael Wöltje; Anandhan Dhanasingh; Jochen Salber; Ruth Knüchel; Martin Zenke
Journal:  PLoS One       Date:  2011-09-14       Impact factor: 3.240

6.  Aminopropyltriethoxysilane-mediated surface functionalization of hydroxyapatite nanoparticles: synthesis, characterization, and in vitro toxicity assay.

Authors:  Shige Wang; Shihui Wen; Mingwu Shen; Rui Guo; Xueyan Cao; Jianhua Wang; Xiangyang Shi
Journal:  Int J Nanomedicine       Date:  2011-12-20

Review 7.  Nanohydroxyapatite application to osteoporosis management.

Authors:  Zairin Noor
Journal:  J Osteoporos       Date:  2013-10-28

8.  Nano-hydroxyapatite/collagen film as a favorable substrate to maintain the phenotype and promote the growth of chondrocytes cultured in vitro.

Authors:  Xianfang Jiang; Yanping Zhong; Li Zheng; Jinmin Zhao
Journal:  Int J Mol Med       Date:  2018-01-26       Impact factor: 4.101

9.  Synthesis of a Novel Electrospun Polycaprolactone Scaffold Functionalized with Ibuprofen for Periodontal Regeneration: An In Vitro andIn Vivo Study.

Authors:  Fareeha Batool; David-Nicolas Morand; Lionel Thomas; Isaac Maximiliano Bugueno; Javier Aragon; Silvia Irusta; Laetitia Keller; Nadia Benkirane-Jessel; Henri Tenenbaum; Olivier Huck
Journal:  Materials (Basel)       Date:  2018-04-10       Impact factor: 3.623

10.  In-situ solvothermal processing of polycaprolactone/hydroxyapatite nanocomposites with enhanced mechanical and biological performance for bone tissue engineering.

Authors:  Saeed Moeini; Mohammad Reza Mohammadi; Abdolreza Simchi
Journal:  Bioact Mater       Date:  2017-04-21
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