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Literature DB >> 19650761

Targeting microRNAs in obesity.

Huangming Xie¹, Lei Sun, Harvey F Lodish.

Abstract

Obesity is a serious health problem worldwide associated with an increased risk of life-threatening diseases such as type 2 diabetes, atherosclerosis, and certain types of cancer. Fundamental for the development of novel therapeutics for obesity and its associated metabolic syndromes is an understanding of the regulation of fat cell development. Recent computational and experimental studies have shown that microRNAs (miRNAs) play a role in metabolic tissue development, lipid metabolism and glucose homeostasis. In addition, many miRNAs are dysregulated in metabolic tissues from obese animals and humans, which potentially contributes to the pathogenesis of obesity-associated complications. In this review we summarize the current state of understanding of the roles of miRNAs in metabolic tissues under normal development and obese conditions, and discuss the potential use of miRNAs as therapeutic targets.

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Year: 2009 PMID： 19650761 PMCID： PMC3197810 DOI： 10.1517/14728220903190707

Source DB: PubMed Journal: Expert Opin Ther Targets ISSN： 1472-8222 Impact factor: 6.902

103 in total

1. Silencing of microRNAs in vivo with 'antagomirs'.

Authors: Jan Krützfeldt; Nikolaus Rajewsky; Ravi Braich; Kallanthottathil G Rajeev; Thomas Tuschl; Muthiah Manoharan; Markus Stoffel
Journal: Nature Date: 2005-10-30 Impact factor: 49.962

Review 2. Adipogenesis: cellular and molecular aspects.

Authors: Bruno Fève
Journal: Best Pract Res Clin Endocrinol Metab Date: 2005-12 Impact factor: 4.690

Review 3. MicroRNAs: a new class of regulatory genes affecting metabolism.

Authors: Jan Krützfeldt; Markus Stoffel
Journal: Cell Metab Date: 2006-07 Impact factor: 27.287

4. MicroRNA and 3T3-L1 pre-adipocyte differentiation.

Authors: Kazuaki Kajimoto; Hiroaki Naraba; Naoharu Iwai
Journal: RNA Date: 2006-07-26 Impact factor: 4.942

Review 5. Role of adipose tissue as an inflammatory organ in human diseases.

Authors: A Schäffler; U Müller-Ladner; J Schölmerich; C Büchler
Journal: Endocr Rev Date: 2006-05-09 Impact factor: 19.871

6. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs.

Authors: Rui Yi; Dónal O'Carroll; Hilda A Pasolli; Zhihong Zhang; Fred S Dietrich; Alexander Tarakhovsky; Elaine Fuchs
Journal: Nat Genet Date: 2006-02-05 Impact factor: 38.330

7. Drosophila lacking microRNA miR-278 are defective in energy homeostasis.

Authors: Aurelio A Teleman; Sushmita Maitra; Stephen M Cohen
Journal: Genes Dev Date: 2006-02-15 Impact factor: 11.361

8. Dicer function is essential for lung epithelium morphogenesis.

Authors: Kelley S Harris; Zhen Zhang; Michael T McManus; Brian D Harfe; Xin Sun
Journal: Proc Natl Acad Sci U S A Date: 2006-02-01 Impact factor: 11.205

9. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.

Authors: Christine Esau; Scott Davis; Susan F Murray; Xing Xian Yu; Sanjay K Pandey; Michael Pear; Lynnetta Watts; Sheri L Booten; Mark Graham; Robert McKay; Amuthakannan Subramaniam; Stephanie Propp; Bridget A Lollo; Susan Freier; C Frank Bennett; Sanjay Bhanot; Brett P Monia
Journal: Cell Metab Date: 2006-02 Impact factor: 27.287

10. The ACAA-insertion/deletion polymorphism at the 3' UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance.

Authors: Gemma Villuendas; José I Botella-Carretero; Abel López-Bermejo; Carme Gubern; Wifredo Ricart; José Manuel Fernández-Real; José L San Millán; Héctor F Escobar-Morreale
Journal: Eur J Endocrinol Date: 2006-08 Impact factor: 6.664

39 in total

1. Reduction of dietary glycaemic load modifies the expression of microRNA potentially associated with energy balance and cancer pathways in pre-menopausal women.

Authors: Susan E McCann; Song Liu; Dan Wang; Jie Shen; Qiang Hu; Chi-Chen Hong; Vicky A Newman; Hua Zhao
Journal: Br J Nutr Date: 2012-05-30 Impact factor: 3.718

2. MicroRNA-27a decreases the level and efficiency of the LDL receptor and contributes to the dysregulation of cholesterol homeostasis.

Authors: M Lucrecia Alvarez; Mahdieh Khosroheidari; Elena Eddy; Stefania C Done
Journal: Atherosclerosis Date: 2015-08-20 Impact factor: 5.162

3. Characterization of microRNA expression profiles in 3T3-L1 adipocytes overexpressing C10orf116.

Authors: Jie Qiu; Xiao-guang Zhou; Xiao-yu Zhou; Chun Zhu; Chun-mei Shi; Chen-bo Ji; Rui Cheng; Yong Li; Xi-rong Guo
Journal: Mol Biol Rep Date: 2013-09-20 Impact factor: 2.316

Review 4. The role of miRNAs in cardiovascular disease risk factors.

Authors: Joy N Jones Buie; Andrew J Goodwin; James A Cook; Perry V Halushka; Hongkuan Fan
Journal: Atherosclerosis Date: 2016-09-22 Impact factor: 5.162

Review 5. The genetics of obesity.

Authors: Blanca M Herrera; Cecilia M Lindgren
Journal: Curr Diab Rep Date: 2010-12 Impact factor: 4.810

10. High-throughput sequencing of microRNAs in peripheral blood mononuclear cells: identification of potential weight loss biomarkers.

Authors: Fermín I Milagro; Jonatan Miranda; María P Portillo; Alfredo Fernandez-Quintela; Javier Campión; J Alfredo Martínez
Journal: PLoS One Date: 2013-01-15 Impact factor: 3.240