Literature DB >> 19649734

Alkaline sucrose as a solvent for delivery of water-insoluble drugs.

V Shah1, D Badia, D Kudasheva.   

Abstract

Alkaline sucrose solution was demonstrated to be a good solvent for the solubilization of water-insoluble drugs. At high concentration and alkaline pH, sucrose solubilizes water-insoluble molecules through intramolecular conformations. Tetracyline and chloramphenicol, when dissolved in alkaline sucrose solution, retained their bactericidal activity. Gel permeation-chromatography analysis and atomic-force-microscopy studies confirmed the formation of sucrose-antibiotics complex.

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Year:  2009        PMID： 19649734     DOI： 10.1007/s12223-009-0030-9

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  18 in total

1.  FTIR and laser-Raman spectra of oligosaccharides in water: characterization of the glycosidic bond.

Authors:  M Kacuráková; M Mathlouthi
Journal:  Carbohydr Res       Date:  1996-04-30       Impact factor: 2.104

2.  Cardiac arrest after autologous marrow infusion.

Authors:  A P Rapoport; J M Rowe; C H Packman; S J Ginsberg
Journal:  Bone Marrow Transplant       Date:  1991-05       Impact factor: 5.483

3.  Sulfhemoglobinemia after dermal application of DMSO.

Authors:  J L Burgess; A P Hamner; W O Robertson
Journal:  Vet Hum Toxicol       Date:  1998-04

4.  Intravenous dimethylsulfoxide therapy causes severe hemolysis mimicking a hemolytic transfusion reaction.

Authors:  M Samoszuk; M E Reid; P T Toy
Journal:  Transfusion       Date:  1983 Sep-Oct       Impact factor: 3.157

5.  DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus.

Authors:  J Ernie Blevins; B Glenn Stanley; Roger D Reidelberger
Journal:  Pharmacol Biochem Behav       Date:  2002 Jan-Feb       Impact factor: 3.533

6.  Sophorolipids improve sepsis survival: effects of dosing and derivatives.

Authors:  Rosemarie Hardin; Joelle Pierre; Robert Schulze; Cathy M Mueller; Sophia L Fu; Sabine R Wallner; Albert Stanek; Vishal Shah; Richard A Gross; Jeremy Weedon; Maja Nowakowski; Michael E Zenilman; Martin H Bluth
Journal:  J Surg Res       Date:  2007-08-23       Impact factor: 2.192

7.  Clinical toxicity of cryopreserved bone marrow graft infusion.

Authors:  J M Davis; S D Rowley; H G Braine; S Piantadosi; G W Santos
Journal:  Blood       Date:  1990-02-01       Impact factor: 22.113

8.  Massive intracranial hemorrhage associated with the ingestion of dimethyl sulfoxide.

Authors:  Hakan Topacoglu; Ozgur Karcioglu; Murat Ozsarac; Deniz Oray; Dogac Niyazi Ozucelik; Yesim Tuncok
Journal:  Vet Hum Toxicol       Date:  2004-06

9.  Transient high grade heart block following autologous bone marrow infusion.

Authors:  M J Styler; D L Topolsky; P A Crilley; V Covalesky; R Bryan; S Bulova; I Brodsky
Journal:  Bone Marrow Transplant       Date:  1992-11       Impact factor: 5.483

10.  Disaccharide conformational flexibility. I. An adiabatic potential energy map for sucrose.

Authors:  V H Tran; J W Brady
Journal:  Biopolymers       Date:  1990 May-Jun       Impact factor: 2.505
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