Literature DB >> 19649080

In vivo brain imaging using a portable 2.9 g two-photon microscope based on a microelectromechanical systems scanning mirror.

Wibool Piyawattanametha1, Eric D Cocker, Laurie D Burns, Robert P Barretto, Juergen C Jung, Hyejun Ra, Olav Solgaard, Mark J Schnitzer.   

Abstract

We present a two-photon microscope that is approximately 2.9 g in mass and 2.0 x 1.9 x 1.1 cm(3) in size and based on a microelectromechanical systems (MEMS) laser-scanning mirror. The microscope has a focusing motor and a micro-optical assembly composed of four gradient refractive index lenses and a dichroic microprism. Fluorescence is captured without the detected emissions reflecting off the MEMS mirror, by use of separate optical fibers for fluorescence collection and delivery of ultrashort excitation pulses. Using this microscope we imaged neocortical microvasculature and tracked the flow of erythrocytes in live mice.

Entities:  

Mesh：

Year:  2009        PMID： 19649080      PMCID： PMC2826365          DOI： 10.1364/ol.34.002309

Source DB:  PubMed          Journal:  Opt Lett        ISSN： 0146-9592            Impact factor:   3.776


  18 in total

1.  In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope.

Authors:  Benjamin A Flusberg; Juergen C Jung; Eric D Cocker; Erik P Anderson; Mark J Schnitzer
Journal:  Opt Lett       Date:  2005-09-01       Impact factor: 3.776

2.  Fiber-optic scanning two-photon fluorescence endoscope.

Authors:  Mon Thiri Myaing; Daniel J MacDonald; Xingde Li
Journal:  Opt Lett       Date:  2006-04-15       Impact factor: 3.776

3.  Nonlinear optical endoscopy based on a double-clad photonic crystal fiber and a MEMS mirror.

Authors:  Ling Fu; Ankur Jain; Huikai Xie; Charles Cranfield; Min Gu
Journal:  Opt Express       Date:  2006-02-06       Impact factor: 3.894

4.  Nonlinear optical endoscope based on a compact two axes piezo scanner and a miniature objective lens.

Authors:  R Le Harzic; M Weinigel; I Riemann; K König; B Messerschmidt
Journal:  Opt Express       Date:  2008-12-08       Impact factor: 3.894

5.  Miniaturized probe for femtosecond laser microsurgery and two-photon imaging.

Authors:  Christopher L Hoy; Nicholas J Durr; Pengyuan Chen; Wibool Piyawattanametha; Hyejun Ra; Olav Solgaard; Adela Ben-Yakar
Journal:  Opt Express       Date:  2008-06-23       Impact factor: 3.894

6.  Miniaturized probe based on a microelectromechanical system mirror for multiphoton microscopy.

Authors:  Woonggyu Jung; Suo Tang; Daniel T McCormic; Tiquiang Xie; Yeh-Chan Ahn; Jianping Su; Ivan V Tomov; Tatiana B Krasieva; Bruce J Tromberg; Zhongping Chen
Journal:  Opt Lett       Date:  2008-06-15       Impact factor: 3.776

7.  Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy.

Authors:  Christian W Freudiger; Wei Min; Brian G Saar; Sijia Lu; Gary R Holtom; Chengwei He; Jason C Tsai; Jing X Kang; X Sunney Xie
Journal:  Science       Date:  2008-12-19       Impact factor: 47.728

8.  Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo.

Authors:  Christoph J Engelbrecht; Richard S Johnston; Eric J Seibel; Fritjof Helmchen
Journal:  Opt Express       Date:  2008-04-14       Impact factor: 3.894

9.  Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans.

Authors:  Michael E Llewellyn; Robert P J Barretto; Scott L Delp; Mark J Schnitzer
Journal:  Nature       Date:  2008-07-06       Impact factor: 49.962

10.  High-speed, miniaturized fluorescence microscopy in freely moving mice.

Authors:  Benjamin A Flusberg; Axel Nimmerjahn; Eric D Cocker; Eran A Mukamel; Robert P J Barretto; Tony H Ko; Laurie D Burns; Juergen C Jung; Mark J Schnitzer
Journal:  Nat Methods       Date:  2008-10-05       Impact factor: 28.547
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  46 in total

1.  Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue.

Authors:  David R Rivera; Christopher M Brown; Dimitre G Ouzounov; Ina Pavlova; Demirhan Kobat; Watt W Webb; Chris Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-17       Impact factor: 11.205

2.  Fiber-optic nonlinear endomicroscopy with focus scanning by using shape memory alloy actuation.

Authors:  Yicong Wu; Yuying Zhang; Jiefeng Xi; Ming-Jun Li; Xingde Li
Journal:  J Biomed Opt       Date:  2010 Nov-Dec       Impact factor: 3.170

3.  Fiber delivered probe for efficient CARS imaging of tissues.

Authors:  Mihaela Balu; Gangjun Liu; Zhongping Chen; Bruce J Tromberg; Eric O Potma
Journal:  Opt Express       Date:  2010-02-01       Impact factor: 3.894

Review 4.  Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide-field, full-color imaging.

Authors:  Cameron M Lee; Christoph J Engelbrecht; Timothy D Soper; Fritjof Helmchen; Eric J Seibel
Journal:  J Biophotonics       Date:  2010-06       Impact factor: 3.207

5.  Two-photon microscopy by wavelength-swept pulses delivered through single-mode fiber.

Authors:  Jeon Woong Kang; Pilhan Kim; Carlo Amadeo Alonzo; Hyunsung Park; Seok H Yun
Journal:  Opt Lett       Date:  2010-01-15       Impact factor: 3.776

6.  Enter the ratrix.

Authors:  Bijan Pesaran; David Kleinfeld
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-11       Impact factor: 11.205

Review 7.  Imaging spinal cord activity in behaving animals.

Authors:  Nicholas A Nelson; Xiang Wang; Daniela Cook; Erin M Carey; Axel Nimmerjahn
Journal:  Exp Neurol       Date:  2019-06-06       Impact factor: 5.330

8.  Two-Photon Fluorescence Imaging.

Authors:  Fan Feng; Heng Mao; Aimin Wang; Liangyi Chen
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

9.  Molecular imaging of conscious, unrestrained mice with AwakeSPECT.

Authors:  Justin S Baba; Christopher J Endres; Catherine A Foss; Sridhar Nimmagadda; Hyeyun Jung; James S Goddard; Seungjoon Lee; John McKisson; Mark F Smith; Alexander V Stolin; Andrew G Weisenberger; Martin G Pomper
Journal:  J Nucl Med       Date:  2013-03-27       Impact factor: 10.057

10.  Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer.

Authors:  Emily S Day; Lissett R Bickford; John H Slater; Nicholas S Riggall; Rebekah A Drezek; Jennifer L West
Journal:  Int J Nanomedicine       Date:  2010-08-09
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