Literature DB >> 19648939

Therapy: Targeted but not trouble-free: efalizumab and PML.

Eamonn S Molloy1, Leonard H Calabrese.   

Abstract

In April 2009, efalizumab was withdrawn from the market for the treatment of psoriasis after reports emerged of an association between long-term therapy and the development of progressive multifocal leukoencephalopathy (PML). This event highlights an urgent need for greater awareness and research into the screening, diagnosis and treatment of this potentially fatal disease in patients undergoing immunosuppressive therapy for chronic inflammatory disorders.

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Year:  2009        PMID: 19648939     DOI: 10.1038/nrrheum.2009.142

Source DB:  PubMed          Journal:  Nat Rev Rheumatol        ISSN: 1759-4790            Impact factor:   20.543


  5 in total

1.  Natalizumab and PML.

Authors:  Richard M Ransohoff
Journal:  Nat Neurosci       Date:  2005-10       Impact factor: 24.884

Review 2.  Progressive multifocal leukoencephalopathy in rheumatic diseases: evolving clinical and pathologic patterns of disease.

Authors:  Leonard H Calabrese; Eamonn S Molloy; DeRen Huang; Richard M Ransohoff
Journal:  Arthritis Rheum       Date:  2007-07

Review 3.  Progressive multifocal leucoencephalopathy in the rheumatic diseases: assessing the risks of biological immunosuppressive therapies.

Authors:  L H Calabrese; E S Molloy
Journal:  Ann Rheum Dis       Date:  2008-12       Impact factor: 19.103

4.  Progressive multifocal leukoencephalopathy: a national estimate of frequency in systemic lupus erythematosus and other rheumatic diseases.

Authors:  Eamonn S Molloy; Leonard H Calabrese
Journal:  Arthritis Rheum       Date:  2009-12

Review 5.  Progressive multifocal leukoencephalopathy in patients with rheumatic diseases: are patients with systemic lupus erythematosus at particular risk?

Authors:  Eamonn S Molloy; Leonard H Calabrese
Journal:  Autoimmun Rev       Date:  2008-12       Impact factor: 9.754

  5 in total
  21 in total

1.  Integrin activation as an alternative treatment approach for inflammatory diseases.

Authors:  Vincent Kam Wai Wong; Liang Liu
Journal:  Acta Pharmacol Sin       Date:  2011-10-31       Impact factor: 6.150

Review 2.  Trafficking of immune cells in the central nervous system.

Authors:  Emma H Wilson; Wolfgang Weninger; Christopher A Hunter
Journal:  J Clin Invest       Date:  2010-05-03       Impact factor: 14.808

3.  Inclusion of rituximab in treatment protocols for non-Hodgkin's lymphomas and risk for progressive multifocal leukoencephalopathy.

Authors:  Marco Tuccori; Daniele Focosi; Corrado Blandizzi; Matteo Pelosini; Sabrina Montagnani; Fabrizio Maggi; Mauro Pistello; Luca Antonioli; Matteo Fornai; Pasquale Pepe; Giuseppe Rossi; Mario Petrini
Journal:  Oncologist       Date:  2010-11-01

4.  JC virus infection of the brain.

Authors:  A K Bag; J K Curé; P R Chapman; G H Roberson; R Shah
Journal:  AJNR Am J Neuroradiol       Date:  2010-03-18       Impact factor: 3.825

Review 5.  Sorting out the risks in progressive multifocal leukoencephalopathy.

Authors:  Leonard H Calabrese; Eamonn Molloy; Joseph Berger
Journal:  Nat Rev Rheumatol       Date:  2014-10-14       Impact factor: 20.543

Review 6.  Progressive multi-focal leucoencephalopathy - driven from rarity to clinical mainstream by iatrogenic immunodeficiency.

Authors:  S A Misbah
Journal:  Clin Exp Immunol       Date:  2017-03-27       Impact factor: 4.330

7.  Progressive multifocal leukoencephalopathy associated with brentuximab vedotin therapy: a report of 5 cases from the Southern Network on Adverse Reactions (SONAR) project.

Authors:  Kenneth R Carson; Scott D Newsome; Ellen J Kim; Nina D Wagner-Johnston; Gloria von Geldern; Craig H Moskowitz; Alison J Moskowitz; Alain H Rook; Pankaj Jalan; Alison W Loren; Daniel Landsburg; Thomas Coyne; Donald Tsai; Dennis W Raisch; LeAnn B Norris; P Brandon Bookstaver; Oliver Sartor; Charles L Bennett
Journal:  Cancer       Date:  2014-04-25       Impact factor: 6.860

8.  Mixed results with modulation of TH-17 cells in human autoimmune diseases.

Authors:  Lawrence Steinman
Journal:  Nat Immunol       Date:  2009-12-17       Impact factor: 25.606

9.  Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.

Authors:  Mohd Hafeez Faridi; Mehmet M Altintas; Camilo Gomez; Juan Camilo Duque; Roberto I Vazquez-Padron; Vineet Gupta
Journal:  Biochim Biophys Acta       Date:  2013-02-26

Review 10.  Identification of targets and new developments in the treatment of multiple sclerosis--focus on cladribine.

Authors:  Clemens Warnke; Heinz Wiendl; Hans-Peter Hartung; Olaf Stüve; Bernd C Kieseier
Journal:  Drug Des Devel Ther       Date:  2010-07-21       Impact factor: 4.162

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