| Literature DB >> 20440079 |
Emma H Wilson1, Wolfgang Weninger, Christopher A Hunter.
Abstract
The CNS is an immune-privileged environment, yet the local control of multiple pathogens is dependent on the ability of immune cells to access and operate within this site. However, inflammation of the distinct anatomical sites (i.e., meninges, cerebrospinal fluid, and parenchyma) associated with the CNS can also be deleterious. Therefore, control of lymphocyte entry and migration within the brain is vital to regulate protective and pathological responses. In this review, several recent advances are highlighted that provide new insights into the processes that regulate leukocyte access to, and movement within, the brain.Entities:
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Year: 2010 PMID： 20440079 PMCID： PMC2860945 DOI： 10.1172/JCI41911
Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808