| Literature DB >> 19648911 |
Elodie Fourcaudot1, Frederic Gambino, Guillaume Casassus, Bernard Poulain, Yann Humeau, Andreas Lüthi.
Abstract
The molecular mechanisms underlying the expression of postsynaptic long-term potentiation (LTP) at glutamatergic synapses are well understood. However, little is known about those that mediate the expression of presynaptic LTP. We found that presynaptic LTP at cortical inputs to the mouse lateral amygdala was blocked and reversed by L-type voltage-dependent Ca(2+) channel (L-VDCC) blockers. Thus, a persistent increase in L-VDCC-mediated glutamate release underlies the expression of presynaptic LTP in the amygdala.Entities:
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Year: 2009 PMID: 19648911 DOI: 10.1038/nn.2378
Source DB: PubMed Journal: Nat Neurosci ISSN: 1097-6256 Impact factor: 24.884