Literature DB >> 10845062

Emotion circuits in the brain.

J E LeDoux1.   

Abstract

The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area. Much of the progress has come from studies of fear, and especially fear conditioning. This work has pinpointed the amygdala as an important component of the system involved in the acquisition, storage, and expression of fear memory and has elucidated in detail how stimuli enter, travel through, and exit the amygdala. Some progress has also been made in understanding the cellular and molecular mechanisms that underlie fear conditioning, and recent studies have also shown that the findings from experimental animals apply to the human brain. It is important to remember why this work on emotion succeeded where past efforts failed. It focused on a psychologically well-defined aspect of emotion, avoided vague and poorly defined concepts such as "affect," "hedonic tone," or "emotional feelings," and used a simple and straightforward experimental approach. With so much research being done in this area today, it is important that the mistakes of the past not be made again. It is also time to expand from this foundation into broader aspects of mind and behavior.

Entities:  

Mesh:

Year:  2000        PMID: 10845062     DOI: 10.1146/annurev.neuro.23.1.155

Source DB:  PubMed          Journal:  Annu Rev Neurosci        ISSN: 0147-006X            Impact factor:   12.449


  2000 in total

1.  Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning.

Authors:  G E Schafe; C M Atkins; M W Swank; E P Bauer; J D Sweatt; J E LeDoux
Journal:  J Neurosci       Date:  2000-11-01       Impact factor: 6.167

2.  The role of ventromedial prefrontal cortex in the recovery of extinguished fear.

Authors:  G J Quirk; G K Russo; J L Barron; K Lebron
Journal:  J Neurosci       Date:  2000-08-15       Impact factor: 6.167

3.  Involvement of human amygdala and orbitofrontal cortex in hunger-enhanced memory for food stimuli.

Authors:  J S Morris; R J Dolan
Journal:  J Neurosci       Date:  2001-07-15       Impact factor: 6.167

4.  Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory.

Authors:  E Santini; R U Muller; G J Quirk
Journal:  J Neurosci       Date:  2001-11-15       Impact factor: 6.167

5.  Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning.

Authors:  S M Rodrigues; G E Schafe; J E LeDoux
Journal:  J Neurosci       Date:  2001-09-01       Impact factor: 6.167

6.  Injections of the NMDA receptor antagonist aminophosphonopentanoic acid into the lateral nucleus of the amygdala block the expression of fear-potentiated startle and freezing.

Authors:  M Fendt
Journal:  J Neurosci       Date:  2001-06-01       Impact factor: 6.167

7.  Damage to the lateral and central, but not other, amygdaloid nuclei prevents the acquisition of auditory fear conditioning.

Authors:  K Nader; P Majidishad; P Amorapanth; J E LeDoux
Journal:  Learn Mem       Date:  2001 May-Jun       Impact factor: 2.460

8.  The amygdala modulates memory consolidation of fear-motivated inhibitory avoidance learning but not classical fear conditioning.

Authors:  A E Wilensky; G E Schafe; J E LeDoux
Journal:  J Neurosci       Date:  2000-09-15       Impact factor: 6.167

9.  Phasic activation of locus ceruleus neurons by the central nucleus of the amygdala.

Authors:  Sebastien Bouret; Adam Duvel; Selim Onat; Susan J Sara
Journal:  J Neurosci       Date:  2003-04-15       Impact factor: 6.167

Review 10.  Facial expressions, their communicatory functions and neuro-cognitive substrates.

Authors:  R J R Blair
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2003-03-29       Impact factor: 6.237

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.