Literature DB >> 19648536

Dissecting the phenotype in genome-wide association studies of psychiatric illness.

Nick Craddock, Kenneth Kendler, Michael Neale, John Nurnberger, Shaun Purcell, Marcella Rietschel, Roy Perlis, Susan L Santangelo, Thomas G Schulze, Thomas Schulze, Jordan W Smoller, Anita Thapar.   

Abstract

Over the past 2 years genome-wide association studies have made major contributions to understanding the genetic architecture of many common human diseases. This editorial outlines the development of such studies in psychiatry and highlights the opportunities for advancing understanding of the biological underpinnings and nosological structure of psychiatric disorders.

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Year:  2009        PMID： 19648536      PMCID： PMC4739810          DOI： 10.1192/bjp.bp.108.063156

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN： 0007-1250            Impact factor:   9.319


  18 in total

Review 1.  Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework.

Authors:  A H Fanous; K S Kendler
Journal:  Mol Psychiatry       Date:  2005-01       Impact factor: 15.992

Review 2.  New links to the pathogenesis of Crohn disease provided by genome-wide association scans.

Authors:  Christopher G Mathew
Journal:  Nat Rev Genet       Date:  2008-01       Impact factor: 53.242

3.  Identification of loci associated with schizophrenia by genome-wide association and follow-up.

Authors:  Michael C O'Donovan; Nicholas Craddock; Nadine Norton; Hywel Williams; Timothy Peirce; Valentina Moskvina; Ivan Nikolov; Marian Hamshere; Liam Carroll; Lyudmila Georgieva; Sarah Dwyer; Peter Holmans; Jonathan L Marchini; Chris C A Spencer; Bryan Howie; Hin-Tak Leung; Annette M Hartmann; Hans-Jürgen Möller; Derek W Morris; Yongyong Shi; GuoYin Feng; Per Hoffmann; Peter Propping; Catalina Vasilescu; Wolfgang Maier; Marcella Rietschel; Stanley Zammit; Johannes Schumacher; Emma M Quinn; Thomas G Schulze; Nigel M Williams; Ina Giegling; Nakao Iwata; Masashi Ikeda; Ariel Darvasi; Sagiv Shifman; Lin He; Jubao Duan; Alan R Sanders; Douglas F Levinson; Pablo V Gejman; Sven Cichon; Markus M Nöthen; Michael Gill; Aiden Corvin; Dan Rujescu; George Kirov; Michael J Owen; Nancy G Buccola; Bryan J Mowry; Robert Freedman; Farooq Amin; Donald W Black; Jeremy M Silverman; William F Byerley; C Robert Cloninger
Journal:  Nat Genet       Date:  2008-09       Impact factor: 38.330

Review 4.  A framework for interpreting genome-wide association studies of psychiatric disorders.

Authors: 
Journal:  Mol Psychiatry       Date:  2008-11-11       Impact factor: 15.992

Review 5.  Reflections on the relationship between psychiatric genetics and psychiatric nosology.

Authors:  Kenneth S Kendler
Journal:  Am J Psychiatry       Date:  2006-07       Impact factor: 18.112

6.  Comparing phenotypes in patients with idiopathic autism to patients with velocardiofacial syndrome (22q11 DS) with and without autism.

Authors:  Wendy R Kates; Kevin M Antshel; Wanda P Fremont; Robert J Shprintzen; Leslie A Strunge; Courtney P Burnette; Anne Marie Higgins
Journal:  Am J Med Genet A       Date:  2007-11-15       Impact factor: 2.802

7.  A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

Authors:  Timothy M Frayling; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Rachel M Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy
Journal:  Science       Date:  2007-04-12       Impact factor: 47.728

8.  Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

Authors:  Eleftheria Zeggini; Michael N Weedon; Cecilia M Lindgren; Timothy M Frayling; Katherine S Elliott; Hana Lango; Nicholas J Timpson; John R B Perry; Nigel W Rayner; Rachel M Freathy; Jeffrey C Barrett; Beverley Shields; Andrew P Morris; Sian Ellard; Christopher J Groves; Lorna W Harries; Jonathan L Marchini; Katharine R Owen; Beatrice Knight; Lon R Cardon; Mark Walker; Graham A Hitman; Andrew D Morris; Alex S F Doney; Mark I McCarthy; Andrew T Hattersley
Journal:  Science       Date:  2007-04-26       Impact factor: 47.728

9.  Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.

Authors:  N Craddock; L Jones; I R Jones; G Kirov; E K Green; D Grozeva; V Moskvina; I Nikolov; M L Hamshere; D Vukcevic; S Caesar; K Gordon-Smith; C Fraser; E Russell; N Norton; G Breen; D St Clair; D A Collier; A H Young; I N Ferrier; A Farmer; P McGuffin; P A Holmans; P Donnelly; M J Owen; M C O'Donovan
Journal:  Mol Psychiatry       Date:  2008-07-01       Impact factor: 15.992

10.  Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

Authors:  Manuel A R Ferreira; Michael C O'Donovan; Yan A Meng; Ian R Jones; Douglas M Ruderfer; Lisa Jones; Jinbo Fan; George Kirov; Roy H Perlis; Elaine K Green; Jordan W Smoller; Detelina Grozeva; Jennifer Stone; Ivan Nikolov; Kimberly Chambert; Marian L Hamshere; Vishwajit L Nimgaonkar; Valentina Moskvina; Michael E Thase; Sian Caesar; Gary S Sachs; Jennifer Franklin; Katherine Gordon-Smith; Kristin G Ardlie; Stacey B Gabriel; Christine Fraser; Brendan Blumenstiel; Matthew Defelice; Gerome Breen; Michael Gill; Derek W Morris; Amanda Elkin; Walter J Muir; Kevin A McGhee; Richard Williamson; Donald J MacIntyre; Alan W MacLean; Clair David St; Michelle Robinson; Margaret Van Beck; Ana C P Pereira; Radhika Kandaswamy; Andrew McQuillin; David A Collier; Nicholas J Bass; Allan H Young; Jacob Lawrence; I Nicol Ferrier; Adebayo Anjorin; Anne Farmer; David Curtis; Edward M Scolnick; Peter McGuffin; Mark J Daly; Aiden P Corvin; Peter A Holmans; Douglas H Blackwood; Hugh M Gurling; Michael J Owen; Shaun M Purcell; Pamela Sklar; Nick Craddock
Journal:  Nat Genet       Date:  2008-09       Impact factor: 38.330
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  30 in total

1.  Cross-Disorder Cognitive Impairments in Youth Referred for Neuropsychiatric Evaluation.

Authors:  Alysa E Doyle; Pieter J Vuijk; Nathan D Doty; Lauren M McGrath; Brian L Willoughby; Ellen H O'Donnell; H Kent Wilson; Mary K Colvin; Deanna C Toner; Kelsey E Hudson; Jessica E Blais; Hillary L Ditmars; Stephen V Faraone; Larry J Seidman; Ellen B Braaten
Journal:  J Int Neuropsychol Soc       Date:  2017-08-04       Impact factor: 2.892

Review 2.  Research review: gene-environment interaction research in youth depression - a systematic review with recommendations for future research.

Authors:  Erin C Dunn; Monica Uddin; S V Subramanian; Jordan W Smoller; Sandro Galea; Karestan C Koenen
Journal:  J Child Psychol Psychiatry       Date:  2011-09-29       Impact factor: 8.982

3.  Cross-Disorder Psychiatric Genomics.

Authors:  Anna R Docherty; Arden A Moscati; Ayman H Fanous
Journal:  Curr Behav Neurosci Rep       Date:  2016-07-02

Review 4.  Prioritizing GWAS results: A review of statistical methods and recommendations for their application.

Authors:  Rita M Cantor; Kenneth Lange; Janet S Sinsheimer
Journal:  Am J Hum Genet       Date:  2010-01       Impact factor: 11.025

5.  Genome-wide association studies: a primer.

Authors:  A Corvin; N Craddock; P F Sullivan
Journal:  Psychol Med       Date:  2009-11-09       Impact factor: 7.723

6.  Modifiers and subtype-specific analyses in whole-genome association studies: a likelihood framework.

Authors:  Phil H Lee; Sarah E Bergen; Roy H Perlis; Patrick F Sullivan; Pamela Sklar; Jordan W Smoller; Shaun M Purcell
Journal:  Hum Hered       Date:  2011-08-17       Impact factor: 0.444

7.  Evaluation of inner retinal layers with optic coherence tomography in vigabatrin-exposed patients.

Authors:  Betül Tuğcu; Mesrure Köseoğlu Bitnel; Fatma Selin Kaya; Betül Tekin Güveli; Dilek Ataklı
Journal:  Neurol Sci       Date:  2017-05-16       Impact factor: 3.307

8.  Ethnicity and Psychiatric Disorders.

Authors:  Armani M Hawes; William G Axinn; Dirgha J Ghimire
Journal:  Ann Psychiatry Ment Health       Date:  2016-06-16

9.  The Kraepelinian dichotomy - going, going... but still not gone.

Authors:  Nick Craddock; Michael J Owen
Journal:  Br J Psychiatry       Date:  2010-02       Impact factor: 9.319

10.  Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.

Authors:  E K Green; M Hamshere; L Forty; K Gordon-Smith; C Fraser; E Russell; D Grozeva; G Kirov; P Holmans; J L Moran; S Purcell; P Sklar; M J Owen; M C O'Donovan; L Jones; I R Jones; N Craddock
Journal:  Mol Psychiatry       Date:  2012-10-16       Impact factor: 15.992
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