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Literature DB >> 1964761

Differential inhibition by nedocromil sodium of superoxide generation elicited by platelet activating factor in human neutrophils.

Abstract

Nedocromil sodium (10(-10) - 10(-9) M) produced a dose-related inhibition of superoxide anion generation induced by platelet activating factor (PAF) in human polymorphonuclear leukocytes (PMNs). At a higher concentration (3 x 10(-7) M), nedocromil sodium significantly inhibited superoxide generation elicited by N-formyl-methionyl-leucylphenylalanine, but was unable to block the response to phorbol dibutyrate. Nedocromil sodium (10(-11) - 10(-5) M) enhanced PAF-stimulated lysozyme release in a non-concentration-dependent manner, and was completely ineffective in depressing PAF-induced release of [3H]arachidonic acid and the rise in cytosolic Ca2+. The preferential inhibitory effects of nedocromil sodium on PAF-induced activation of superoxide generation may provide insight into the therapeutic action of this drug as an anti-asthmatic agent.

Entities: Chemical Gene Species

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Year: 1990 PMID： 1964761 DOI： 10.1007/bf01997614

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

25 in total

1. Effect of an inhibitor of protein kinase C on human polymorphonuclear leukocyte degranulation.

Authors: W Salzer; C Gerard; C McCall
Journal: Biochem Biophys Res Commun Date: 1987-10-29 Impact factor: 3.575

2. Double stimulation with FMLP and Con A restores the activation of the respiratory burst but not of the phosphoinositide turnover in Ca2+-depleted human neutrophils. A further example of dissociation between stimulation of the NADPH oxidase and phosphoinositide turnover.

Authors: F Rossi; M Grzeskowiak; V Della Bianca
Journal: Biochem Biophys Res Commun Date: 1986-10-15 Impact factor: 3.575

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Authors: H J Cohen; M E Chovaniec
Journal: J Clin Invest Date: 1978-04 Impact factor: 14.808

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Authors: B Dewald; M Baggiolini
Journal: Biochem Pharmacol Date: 1987-08-01 Impact factor: 5.858

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Authors: A Böyum
Journal: Scand J Clin Lab Invest Suppl Date: 1968

6. The clinical development of a new agent for the treatment of airway inflammation, nedocromil sodium (Tilade).

Authors: R M Auty
Journal: Eur J Respir Dis Suppl Date: 1986

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Authors: P G Bradford; R P Rubin
Journal: Mol Pharmacol Date: 1985-01 Impact factor: 4.436

8. Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.

Authors: C C Cox; R W Dougherty; B R Ganong; R M Bell; J E Niedel; R Snyderman
Journal: J Immunol Date: 1986-06-15 Impact factor: 5.422

9. Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels.

Authors: F Di Virgilio; D P Lew; T Pozzan
Journal: Nature Date: 1984 Aug 23-29 Impact factor: 49.962

3. Cromoglycate and nedocromil enhanced the reactive oxygen species-dependent suppressions with, but not without, dexamethasone in ischaemic and histamine paw oedema of mice.

Authors: Y Oyanagui
Journal: Mediators Inflamm Date: 1997 Impact factor: 4.711

3 in total