Literature DB >> 18475598

Effect of nedocromil sodium on polymorphonuclear leukocyte plasma membrane.

A Kantar1, N Oggiano, P L Giorgi, G V Coppa, R Gabbianelli, S Bruni, F M Cutrona, R Fiorini.   

Abstract

The effect of nedocromil sodium on the plasma membrane fluidity of polymorphonuclear leukocytes (PMNs) was investigated by measuring steady-state fluorescence anisotropy of 1-[4-trimethylammonium-phenyl]-6-phenyl- 1,3,5-hexatriene (TMA-DPH) incorporated in the membrane. Our results show that nedocromil sodium 300 muM significantly decreased membrane fluidity of PMNs. The decrease in membrane fluidity of PMNs induced by fMLP was abolished in the presence of nedocromil sodium. These data suggest that nedocromil sodium interferes with the plasma membranes of PMNs and modulates their activities.

Entities:  

Year:  1994        PMID： 18475598      PMCID： PMC2365593          DOI： 10.1155/S0962935194000700

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  16 in total

Review 1.  Leucocytes and pulmonary disorders: mobilization, activation and role in pathology.

Authors:  A Shock; G J Laurent
Journal:  Mol Aspects Med       Date:  1990

2.  Alterations in membrane fluidity of diabetic polymorphonuclear leukocytes.

Authors:  A Kantar; P L Giorgi; G Curatola; R Fiorini
Journal:  Biochem Med Metab Biol       Date:  1991-12

Review 3.  On the principles of functional ordering in biological membranes.

Authors:  P K Kinnunen
Journal:  Chem Phys Lipids       Date:  1991-03       Impact factor: 3.329

Review 4.  Activation of the neutrophil respiratory burst by chemoattractants: regulation of the N-formyl peptide receptor in the plasma membrane.

Authors:  A J Jesaitis; R A Allen
Journal:  J Bioenerg Biomembr       Date:  1988-12       Impact factor: 2.945

5.  Changes of fluorescence anisotropy in plasma membrane of human polymorphonuclear leukocytes during the respiratory burst phenomenon.

Authors:  R Fiorini; G Curatola; E Bertoli; P L Giorgi; A Kantar
Journal:  FEBS Lett       Date:  1990-10-29       Impact factor: 4.124

6.  Alterations of the respiratory burst of polymorphonuclear leukocytes from diabetic children. A chemiluminescence study.

Authors:  A Kantar; G Wilkins; B Swoboda; G P Littarru; E Bertoli; C Catassi; G Coppa; P L Giorgi
Journal:  Acta Paediatr Scand       Date:  1990-05

7.  Effects of nedocromil sodium on in vitro induced migration, activation, and mediator release from human granulocytes.

Authors:  P L Bruijnzeel; R A Warringa; P T Kok; M L Hamelink; H Kreukniet; L Koenderman
Journal:  J Allergy Clin Immunol       Date:  1993-07       Impact factor: 10.793

8.  Effects of nedocromil sodium on the binding of N-formyl-methionyl-leucyl-phenylalanine in human neutrophils.

Authors:  D G Peroni; P Melotti; G L Piacentini; C Bonizzato; A L Boner
Journal:  Agents Actions       Date:  1992-07

Review 9.  Activation of the respiratory burst oxidase in neutrophils: on the role of membrane-derived second messengers, Ca++, and protein kinase C.

Authors:  J D Lambeth
Journal:  J Bioenerg Biomembr       Date:  1988-12       Impact factor: 2.945

10.  Differential inhibition by nedocromil sodium of superoxide generation elicited by platelet activating factor in human neutrophils.

Authors:  R P Rubin; R H Thompson; M S Naps
Journal:  Agents Actions       Date:  1990-11
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