| Literature DB >> 19647429 |
Brian F McGuinness1, Carolyn DiIanni Carroll, Lisa Guise Zawacki, Guizhen Dong, Cangming Yang, Doug W Hobbs, Biji Jacob-Samuel, James W Hall, Chung-Her Jenh, Joseph A Kozlowski, Gopinadhan N Anilkumar, Stuart B Rosenblum.
Abstract
High-throughput screening of an encoded combinatorial aryl piperazine library led to the identification of a novel series of potent piperazinyl-piperidine based CXCR3 antagonists. Analogs of the initial hit were synthesized via solid and solution phase methods to probe the influence of structure on the CXCR3 binding of these molecules. Various functional groups were found to contribute to the overall potency and essential molecular features were identified.Entities:
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Year: 2009 PMID： 19647429 DOI： 10.1016/j.bmcl.2009.07.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823