| Literature DB >> 19647237 |
Miaoe Yan1, Jing Wang, Xiaoke Wu, Lihui Hou, Haixue Kuang, Yongyan Wang.
Abstract
Insulin resistance on porcine granulosa cells was induced by wortmannin, the phosphatidylinositol-3-kinase inhibitor, and insulin signaling key molecules were investigated including glut(4) and mitogen-activated protein kinase. Granulosa insulin resistance decreased glut(4) expression but increased mitogen-activated protein kinase, indicating the cross talk between the metabolic and mitogenic pathways of insulin signaling in the ovary.Entities:
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Year: 2009 PMID： 19647237 DOI： 10.1016/j.fertnstert.2009.06.019
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329