| Literature DB >> 19646809 |
Rai-Hua Lai1, Ya-Wen Hsiao, Mei-Jung Wang, Huan-Yu Lin, Chew-Wun Wu, Chin-Wen Chi, Anna Fen-Yau Li, Yuh-Shan Jou, Jeou-Yuan Chen.
Abstract
Members of the suppressor of cytokine-induced signaling (SOCS) family are negative regulators of cytokine signaling pathways. By mRNA differential display, we showed that SOCS6 was frequently down-regulated in gastric cancer (GC). Our data showed that allelic loss and promoter hypermethylation may account for the major mechanisms leading to SOCS6 inactivation. Ectopic expression of SOCS6 suppressed cell growth and colony formation, in part through eliciting intrinsic apoptotic pathway, accompanied with decreased mitochondrial membrane potential. Taken together, this study provides molecular and functional data supporting the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19646809 DOI： 10.1016/j.canlet.2009.06.025
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679