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Literature DB >> 19645954

Enhancement of the bias component of downbeat nystagmus after lesions of the nodulus and uvula.

Mark F Walker¹, Jing Tian, Xiaoyan Shan, Howard Ying, Rafael J Tamargo, David S Zee.

Abstract

In two monkeys, we recorded spontaneous eye movements before and after ablation of the cerebellar nodulus and uvula (Nod/Uv). In both monkeys, there was an increase in upward ocular drift (downbeat nystagmus [DBN]) in darkness (M1: 1.5 degrees/s pre, 3.4 degrees/s post; M2: 1.3 degrees/s pre, 7.0 degrees/s post), but not in light. There was little effect of orbital position on drift velocity. These findings suggest that the Nod/Uv may play a role in the bias component of DBN.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2009 PMID： 19645954 PMCID： PMC2758645 DOI： 10.1111/j.1749-6632.2008.03717.x

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

8 in total

1. Control of spatial orientation of the angular vestibuloocular reflex by the nodulus and uvula.

Authors: S Wearne; T Raphan; B Cohen
Journal: J Neurophysiol Date: 1998-05 Impact factor: 2.714

2. Abolished tilt suppression of the vestibulo-ocular reflex caused by a selective uvulo-nodular lesion.

Authors: G Wiest; L Deecke; S Trattnig; C Mueller
Journal: Neurology Date: 1999-01-15 Impact factor: 9.910

3. Effects of ablation of flocculus and paraflocculus of eye movements in primate.

Authors: D S Zee; A Yamazaki; P H Butler; G Gücer
Journal: J Neurophysiol Date: 1981-10 Impact factor: 2.714

4. Smooth pursuit in patients with downbeat nystagmus.

Authors: Stefan Glasauer; Muna Hoshi; Ulrich Büttner
Journal: Ann N Y Acad Sci Date: 2005-04 Impact factor: 5.691

5. Gravity dependence of ocular drift in patients with cerebellar downbeat nystagmus.

Authors: Sarah Marti; Antonella Palla; Dominik Straumann
Journal: Ann Neurol Date: 2002-12 Impact factor: 10.422

6. A model-based theory on the origin of downbeat nystagmus.

Authors: Sarah Marti; Dominik Straumann; Ulrich Büttner; Stefan Glasauer
Journal: Exp Brain Res Date: 2008-05-08 Impact factor: 1.972

7. Inertial representation of angular motion in the vestibular system of rhesus monkeys. II. Otolith-controlled transformation that depends on an intact cerebellar nodulus.

Authors: D E Angelaki; B J Hess
Journal: J Neurophysiol Date: 1995-05 Impact factor: 2.714

8. Structural and functional MRIs disclose cerebellar pathologies in idiopathic downbeat nystagmus.

Authors: K Hüfner; T Stephan; R Kalla; A Deutschländer; J Wagner; M Holtmannspötter; G Schulte-Altedorneburg; M Strupp; T Brandt; S Glasauer
Journal: Neurology Date: 2007-09-11 Impact factor: 9.910

8 in total

4 in total

Enhancement of the bias component of downbeat nystagmus after lesions of the nodulus and uvula.

1. Control of spatial orientation of the angular vestibuloocular reflex by the nodulus and uvula.

2. Abolished tilt suppression of the vestibulo-ocular reflex caused by a selective uvulo-nodular lesion.

3. Effects of ablation of flocculus and paraflocculus of eye movements in primate.

4. Smooth pursuit in patients with downbeat nystagmus.

5. Gravity dependence of ocular drift in patients with cerebellar downbeat nystagmus.

6. A model-based theory on the origin of downbeat nystagmus.

7. Inertial representation of angular motion in the vestibular system of rhesus monkeys. II. Otolith-controlled transformation that depends on an intact cerebellar nodulus.

8. Structural and functional MRIs disclose cerebellar pathologies in idiopathic downbeat nystagmus.

Review 1. Eye Movement Disorders and the Cerebellum.

2. The ataxic mouse as a model for studying downbeat nystagmus.

3. Cerebellum and ocular motor control.

Review 4. A neurologist and ataxia: using eye movements to learn about the cerebellum.