Literature DB >> 19644479

Tissue transglutaminase inhibition as treatment for diabetic glomerular scarring: it's good to be glueless.

Jeffrey R Schelling1.   

Abstract

Diabetic nephropathy is characterized by enhanced glomerular and tubulointerstitial deposition of extracellular matrix proteins, which are bound together by tissue transglutaminase (TG2). Huang et al. demonstrate that infusion of a novel TG2 inhibitor in diabetic rats prevented renal scarring and albuminuria and preserved glomerular filtration rate. These studies confirm the role of TG2 in the pathogenesis of diabetic nephropathy and add to an emerging literature that demonstrates that TG2 is an attractive therapeutic target for sclerosing kidney diseases.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19644479      PMCID： PMC3580154          DOI： 10.1038/ki.2009.179

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  10 in total

1.  Increases in renal epsilon-(gamma-glutamyl)-lysine crosslinks result from compartment-specific changes in tissue transglutaminase in early experimental diabetic nephropathy: pathologic implications.

Authors:  N J Skill; M Griffin; A M El Nahas; T Sanai; J L Haylor; M Fisher; M F Jamie; N N Mould; T S Johnson
Journal:  Lab Invest       Date:  2001-05       Impact factor: 5.662

2.  Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease.

Authors:  Tim S Johnson; Marie Fisher; John L Haylor; Zoe Hau; N James Skill; Richard Jones; Robert Saint; Ian Coutts; Melissa E Vickers; A Meguid El Nahas; Martin Griffin
Journal:  J Am Soc Nephrol       Date:  2007-11-14       Impact factor: 10.121

Review 3.  The role of transglutaminase-2 and its substrates in human diseases.

Authors:  Francesco Facchiano; Antonio Facchiano; Angelo M Facchiano
Journal:  Front Biosci       Date:  2006-05-01

4.  Identification of tissue transglutaminase as the autoantigen of celiac disease.

Authors:  W Dieterich; T Ehnis; M Bauer; P Donner; U Volta; E O Riecken; D Schuppan
Journal:  Nat Med       Date:  1997-07       Impact factor: 53.440

5.  Expression of transforming growth factor-beta isoforms in human glomerular diseases.

Authors:  T Yamamoto; N A Noble; A H Cohen; C C Nast; A Hishida; L I Gold; W A Border
Journal:  Kidney Int       Date:  1996-02       Impact factor: 10.612

6.  Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration.

Authors:  Nasim Shweke; Nada Boulos; Chantal Jouanneau; Sophie Vandermeersch; Gerry Melino; Jean-Claude Dussaule; Christos Chatziantoniou; Pierre Ronco; Jean-Jacques Boffa
Journal:  Am J Pathol       Date:  2008-08-07       Impact factor: 4.307

7.  Tissue transglutaminase and the progression of human renal scarring.

Authors:  Timothy S Johnson; Ahmed F El-Koraie; N James Skill; Nahed M Baddour; A Meguid El Nahas; Melvin Njloma; Ahmed G Adam; Martin Griffin
Journal:  J Am Soc Nephrol       Date:  2003-08       Impact factor: 10.121

Review 8.  Transglutaminases: nature's biological glues.

Authors:  Martin Griffin; Rita Casadio; Carlo M Bergamini
Journal:  Biochem J       Date:  2002-12-01       Impact factor: 3.857

9.  Transglutaminase inhibition ameliorates experimental diabetic nephropathy.

Authors:  Linghong Huang; John L Haylor; Zoe Hau; Richard A Jones; Melissa E Vickers; Bart Wagner; Martin Griffin; Robert E Saint; Ian G C Coutts; A Meguid El Nahas; Timothy S Johnson
Journal:  Kidney Int       Date:  2009-06-24       Impact factor: 10.612

10.  Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells.

Authors:  S Kojima; K Nara; D B Rifkin
Journal:  J Cell Biol       Date:  1993-04       Impact factor: 10.539
  10 in total
  9 in total

Review 1.  Transglutaminase regulation of cell function.

Authors:  Richard L Eckert; Mari T Kaartinen; Maria Nurminskaya; Alexey M Belkin; Gozde Colak; Gail V W Johnson; Kapil Mehta
Journal:  Physiol Rev       Date:  2014-04       Impact factor: 37.312

Review 2.  Transglutaminse 2 and EGGL, the protein cross-link formed by transglutaminse 2, as therapeutic targets for disabilities of old age.

Authors:  William Bains
Journal:  Rejuvenation Res       Date:  2013-12       Impact factor: 4.663

3.  Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis.

Authors:  Hyun Jik Lee; Young Hyun Jung; Gee Euhn Choi; Jun Sung Kim; Chang Woo Chae; Jae Ryong Lim; Seo Yihl Kim; Jee Hyeon Yoon; Ji Hyeon Cho; Sei-Jung Lee; Ho Jae Han
Journal:  Cell Death Differ       Date:  2020-07-23       Impact factor: 15.828

4.  NADPH Oxidase Inhibition in Fibrotic Pathologies.

Authors:  Karen Bernard; Victor J Thannickal
Journal:  Antioxid Redox Signal       Date:  2020-03-04       Impact factor: 7.468

5.  Aldosterone nongenomically induces angiotensin II receptor dimerization in rat kidney: role of mineralocorticoid receptor and NADPH oxidase.

Authors:  Kittisak Sinphitukkul; Krissanapong Manotham; Somchai Eiam-Ong; Somchit Eiam-Ong
Journal:  Arch Med Sci       Date:  2019-08-22       Impact factor: 3.318

6.  Ginkgo biloba leaf extract prevents diabetic nephropathy through the suppression of tissue transglutaminase.

Authors:  Xiaoyan Yu; Qing Su; Jianan Geng; Hui Liu; Yumeng Liu; Jinming Liu; Yan Shi; Yinggang Zou
Journal:  Exp Ther Med       Date:  2021-02-08       Impact factor: 2.447

7.  Spatially Resolved Transcriptomes of Mammalian Kidneys Illustrate the Molecular Complexity and Interactions of Functional Nephron Segments.

Authors:  Arti M Raghubar; Duy T Pham; Xiao Tan; Laura F Grice; Joanna Crawford; Pui Yeng Lam; Stacey B Andersen; Sohye Yoon; Siok Min Teoh; Nicholas A Matigian; Anne Stewart; Leo Francis; Monica S Y Ng; Helen G Healy; Alexander N Combes; Andrew J Kassianos; Quan Nguyen; Andrew J Mallett
Journal:  Front Med (Lausanne)       Date:  2022-07-07

8.  Altered Gene Expression of Muscle Satellite Cells Contributes to Agerelated Sarcopenia in Mice.

Authors:  Zsofia Budai; Laszlo Balogh; Zsolt Sarang
Journal:  Curr Aging Sci       Date:  2018

9.  Urinary Metabolomic Markers of Protein Glycation, Oxidation, and Nitration in Early-Stage Decline in Metabolic, Vascular, and Renal Health.

Authors:  Jinit Masania; Gernot Faustmann; Attia Anwar; Hildegard Hafner-Giessauf; Nasir Rajpoot; Johanna Grabher; Kashif Rajpoot; Beate Tiran; Barbara Obermayer-Pietsch; Brigitte M Winklhofer-Roob; Johannes M Roob; Naila Rabbani; Paul J Thornalley
Journal:  Oxid Med Cell Longev       Date:  2019-11-19       Impact factor: 6.543
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.