Literature DB >> 19640708

Synthesis of biotinylated OSW-1.

Ying Kang1, Changgang Lou, Kausar Begam Riaz Ahmed, Peng Huang, Zhendong Jin.   

Abstract

OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps.

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Year:  2009        PMID： 19640708      PMCID： PMC2762400          DOI： 10.1016/j.bmcl.2009.07.062

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Display cloning: functional identification of natural product receptors using cDNA-phage display.

Authors:  P P Sche; K M McKenzie; J D White; D J Austin
Journal:  Chem Biol       Date:  1999-10

2.  First Total Synthesis of an Exceptionally Potent Antitumor Saponin, OSW-1.

Authors:  Shaojiang Deng; Biao Yu; Yun Lou; Yongzheng Hui
Journal:  J Org Chem       Date:  1999-01-08       Impact factor: 4.354

3.  A new strategy for the stereoselective introduction of steroid side chain via alpha-alkoxy vinyl cuprates: total synthesis of a highly potent antitumor natural product OSW-1.

Authors:  W Yu; Z Jin
Journal:  J Am Chem Soc       Date:  2001-04-11       Impact factor: 15.419

4.  OSW saponins: facile synthesis toward a new type of structures with potent antitumor activities.

Authors:  Bingfeng Shi; Pingping Tang; Xiaoyi Hu; Jun O Liu; Biao Yu
Journal:  J Org Chem       Date:  2005-12-09       Impact factor: 4.354

5.  A total synthesis of OSW-1.

Authors:  Jie Xue; Peng Liu; Yanbin Pan; Zhongwu Guo
Journal:  J Org Chem       Date:  2007-12-08       Impact factor: 4.354

6.  On the relationship of OSW-1 to the cephalostatins.

Authors:  C Guo; T G LaCour; P L Fuchs
Journal:  Bioorg Med Chem Lett       Date:  1999-02-08       Impact factor: 2.823

7.  OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action.

Authors:  Yan Zhou; Celia Garcia-Prieto; Dennis A Carney; Rui-hua Xu; Helene Pelicano; Ying Kang; Wensheng Yu; Changgang Lou; Seiji Kondo; Jinsong Liu; David M Harris; Zeev Estrov; Michael J Keating; Zhendong Jin; Peng Huang
Journal:  J Natl Cancer Inst       Date:  2005-12-07       Impact factor: 13.506

8.  Total synthesis of the anticancer natural product OSW-1.

Authors:  Wensheng Yu; Zhendong Jin
Journal:  J Am Chem Soc       Date:  2002-06-12       Impact factor: 15.419

9.  Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.

Authors:  M Kuroda; Y Mimaki; A Yokosuka; Y Sashida; J A Beutler
Journal:  J Nat Prod       Date:  2001-01       Impact factor: 4.050

10.  Synthesis of a cholestane glycoside OSW-1 with potent cytostatic activity.

Authors:  Jacek W Morzycki; Agnieszka Wojtkielewicz
Journal:  Carbohydr Res       Date:  2002-08-16       Impact factor: 2.104
  10 in total

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