PURPOSE: We investigated the relationship between scintigraphic infarct size and neutrophil counts after acute myocardial infarction (AMI), which has not been adequately studied with imaging tools. METHODS: Twenty-eight consecutive patients with anterior AMI were included in the study. Total white blood cell (WBC), neutrophil counts, creatine kinase-myocardial band (CKMB), and cardiac troponin (cTnT) were obtained at admission and daily during the first 72 h after a patient's arrival. Single photon emission computed tomography studies were performed at a median interval of 4 days (range, 3-5 days) after the AMI. The severity scores of perfusion defects were calculated. WBC and neutrophil counts correlated with enzymatic and single photon emission computed tomography infarct size. RESULTS: Leukocyte and neutrophil counts on admission and first day were positively correlated with peak CKMB, peak cTnT, and scintigraphic infarct size. There were no statistical correlations on the second and third days (P>0.05). The most significant relationship was between basal neutrophil counts and scintigraphic infarct size (r = 0.602, P<0.001). Overall, the correlation coefficients with scintigraphy were better than those with peak CKMB and cTnT levels for both WBC and neutrophil counts. CONCLUSION: Measuring basal neutrophil counts may be considered as an alternative solution in the prediction of infarct size.
PURPOSE: We investigated the relationship between scintigraphic infarct size and neutrophil counts after acute myocardial infarction (AMI), which has not been adequately studied with imaging tools. METHODS: Twenty-eight consecutive patients with anterior AMI were included in the study. Total white blood cell (WBC), neutrophil counts, creatine kinase-myocardial band (CKMB), and cardiac troponin (cTnT) were obtained at admission and daily during the first 72 h after a patient's arrival. Single photon emission computed tomography studies were performed at a median interval of 4 days (range, 3-5 days) after the AMI. The severity scores of perfusion defects were calculated. WBC and neutrophil counts correlated with enzymatic and single photon emission computed tomography infarct size. RESULTS: Leukocyte and neutrophil counts on admission and first day were positively correlated with peak CKMB, peak cTnT, and scintigraphic infarct size. There were no statistical correlations on the second and third days (P>0.05). The most significant relationship was between basal neutrophil counts and scintigraphic infarct size (r = 0.602, P<0.001). Overall, the correlation coefficients with scintigraphy were better than those with peak CKMB and cTnT levels for both WBC and neutrophil counts. CONCLUSION: Measuring basal neutrophil counts may be considered as an alternative solution in the prediction of infarct size.
Authors: Jeong-Ju Yoo; Eun Ju Cho; Bora Lee; Sang Gyune Kim; Young Seok Kim; Yun Bin Lee; Jeong-Hoon Lee; Su Jong Yu; Yoon Jun Kim; Jung-Hwan Yoon Journal: Gut Liver Date: 2018-11-15 Impact factor: 4.519
Authors: Chen Chen; Bai Lin Cong; Min Wang; Muhammad Abdullah; Xiao Long Wang; Yin Hua Zhang; Shun Ji Xu; Lan Cui Journal: Integr Med Res Date: 2018-03-08
Authors: Niek J Pluijmert; Melina C den Haan; Vanessa L van Zuylen; Paul Steendijk; Hetty C de Boer; Anton J van Zonneveld; Willem E Fibbe; Martin J Schalij; Paul H A Quax; Douwe E Atsma Journal: PLoS One Date: 2019-06-14 Impact factor: 3.240
Authors: Albert Dahdah; Jillian Johnson; Sreejit Gopalkrishna; Robert M Jaggers; Darren Webb; Andrew J Murphy; Nordin M J Hanssen; Beatriz Y Hanaoka; Prabhakara R Nagareddy Journal: Front Cell Dev Biol Date: 2022-03-02