Literature DB >> 19636633

MicroRNAs: novel diagnostic and therapeutic tools for pancreatic ductal adenocarcinoma?

Wolf Arif Mardin1, Soeren Torge Mees.   

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is known for its very poor overall prognosis, making tools for early diagnosis and new therapeutic modalities urgently needed. MicroRNAs (miRNAs), endogenous noncoding RNA molecules of approximately 22 nt, have gained attention as an epigenetic component involved in the development of many cancers, including PDAC. miRNA expression profiles of varying pancreatic tissues have identified a number of differentially expressed miRNAs and seem to be able to differentiate between three tissues of clinical importance: normal pancreas, chronic pancreatitis, and PDAC. This article gathers our current knowledge of differentially expressed miRNAs in pancreatic tissues with relevance to PDAC and presents potential diagnostic and therapeutic opportunities.

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Year:  2009        PMID： 19636633     DOI： 10.1245/s10434-009-0623-1

Source DB:  PubMed          Journal:  Ann Surg Oncol        ISSN： 1068-9265            Impact factor:   5.344


  21 in total

Review 1.  Aberrant epigenetic grooming of miRNAs in pancreatic cancer: a systems biology perspective.

Authors:  Asfar S Azmi; Frances W J Beck; Bin Bao; Ramzi M Mohammad; Fazlul H Sarkar
Journal:  Epigenomics       Date:  2011-12       Impact factor: 4.778

2.  Molecular characterization of patient-derived human pancreatic tumor xenograft models for preclinical and translational development of cancer therapeutics.

Authors:  Mike Mattie; Ashley Christensen; Mi Sook Chang; William Yeh; Suzanne Said; Yuriy Shostak; Linnette Capo; Alla Verlinsky; Zili An; Ingrid Joseph; Yi Zhang; Sathish Kumar-Ganesan; Karen Morrison; David Stover; Pia Challita-Eid
Journal:  Neoplasia       Date:  2013-10       Impact factor: 5.715

3.  Downregulation of miR-301a-3p sensitizes pancreatic cancer cells to gemcitabine treatment via PTEN.

Authors:  Xiang Xia; Kundong Zhang; Guangtao Luo; Gang Cen; Jun Cao; Kejian Huang; Zhengjun Qiu
Journal:  Am J Transl Res       Date:  2017-04-15       Impact factor: 4.060

4.  MicroRNA-424-5p suppresses the expression of SOCS6 in pancreatic cancer.

Authors:  Kemin Wu; Guohuang Hu; Xin He; Peng Zhou; Jian Li; Bin He; Weijia Sun
Journal:  Pathol Oncol Res       Date:  2013-05-09       Impact factor: 3.201

5.  Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors.

Authors:  Lorenzo F Sempere; Meir Preis; Todd Yezefski; Haoxu Ouyang; Arief A Suriawinata; Asli Silahtaroglu; Jose R Conejo-Garcia; Sakari Kauppinen; Wendy Wells; Murray Korc
Journal:  Clin Cancer Res       Date:  2010-08-03       Impact factor: 12.531

6.  Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc.

Authors:  Y Liu; X Li; S Zhu; J-g Zhang; M Yang; Q Qin; S-c Deng; B Wang; K Tian; L Liu; Y Niu; C-y Wang; G Zhao
Journal:  Gene Ther       Date:  2015-04-28       Impact factor: 5.250

7.  MicroRNA expression aids the preoperative diagnosis of pancreatic ductal adenocarcinoma.

Authors:  Nicole C Panarelli; Yao-Tseng Chen; Xi K Zhou; Naoki Kitabayashi; Rhonda K Yantiss
Journal:  Pancreas       Date:  2012-07       Impact factor: 3.327

8.  Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer.

Authors:  Jin-Hyeok Hwang; Johannes Voortman; Elisa Giovannetti; Seth M Steinberg; Leticia G Leon; Yong-Tae Kim; Niccola Funel; Joo Kyung Park; Min A Kim; Gyeong Hoon Kang; Sun-Whe Kim; Marco Del Chiaro; Godefridus J Peters; Giuseppe Giaccone
Journal:  PLoS One       Date:  2010-05-14       Impact factor: 3.240

9.  The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL.

Authors:  Peng Wang; Liping Zhuang; Juan Zhang; Jie Fan; Jianmin Luo; Hao Chen; Kun Wang; Luming Liu; Zhen Chen; Zhiqiang Meng
Journal:  Mol Oncol       Date:  2012-11-07       Impact factor: 6.603

10.  Prenatal exposure to TCDD triggers significant modulation of microRNA expression profile in the thymus that affects consequent gene expression.

Authors:  Narendra P Singh; Udai P Singh; Hongbing Guan; Prakash Nagarkatti; Mitzi Nagarkatti
Journal:  PLoS One       Date:  2012-09-14       Impact factor: 3.240
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