| Literature DB >> 19632833 |
Jing Zhou1, Lei Duan, Huaming Chen, Xiaomei Ren, Zhang Zhang, Fengtao Zhou, Jinsong Liu, Duanqing Pei, Ke Ding.
Abstract
2-Piperazinyl naphthoquinones (2) and 2-piperidinyl naphthoquinones (3) were designed and synthesized as new cytotoxic and apoptosis inducing agents by utilizing the anti-parasite drug atovaquone as lead compound. Several compounds displayed significantly improved cytotoxic activities against a panel of cancer cell lines than that of atovaquone. These compounds also induced apoptosis through activating pro-apoptotic caspases 9 and 3.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19632833 DOI： 10.1016/j.bmcl.2009.07.044
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823