| Literature DB >> 19632114 |
Yukiko Hiraiwa1, Akihiro Morinaka, Takayoshi Fukushima, Toshiaki Kudo.
Abstract
4-Butyl-3-methylphthalic acid was recognized as a metallo-beta-lactamase inhibitor. The structure-activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1.Entities:
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Year: 2009 PMID： 19632114 DOI： 10.1016/j.bmcl.2009.07.018
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823