Literature DB >> 20121112

Evolving carbapenemases: can medicinal chemists advance one step ahead of the coming storm?

Peter Oelschlaeger1, Ni Ai, Kevin T Duprez, William J Welsh, Jeffrey H Toney.   

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Year:  2010        PMID： 20121112      PMCID： PMC2855403          DOI： 10.1021/jm9012938

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  124 in total

1.  Emergence of IMP-4 metallo-beta-lactamase in a clinical isolate from Australia.

Authors:  Anton Y Peleg; Clare Franklin; Jan Bell; Denis W Spelman
Journal:  J Antimicrob Chemother       Date:  2004-07-28       Impact factor: 5.790

2.  Hydroxyl groups in the (beta)beta sandwich of metallo-beta-lactamases favor enzyme activity: a computational protein design study.

Authors:  Peter Oelschlaeger; Stephen L Mayo
Journal:  J Mol Biol       Date:  2005-07-15       Impact factor: 5.469

3.  Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.

Authors:  Ørjan Samuelsen; Mariana Castanheira; Timothy R Walsh; James Spencer
Journal:  Antimicrob Agents Chemother       Date:  2008-06-16       Impact factor: 5.191

4.  New predictive models for blood-brain barrier permeability of drug-like molecules.

Authors:  Sandhya Kortagere; Dmitriy Chekmarev; William J Welsh; Sean Ekins
Journal:  Pharm Res       Date:  2008-04-16       Impact factor: 4.200

Review 5.  The changing epidemiology of resistance.

Authors:  Peter M Hawkey; Annie M Jones
Journal:  J Antimicrob Chemother       Date:  2009-09       Impact factor: 5.790

6.  Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.

Authors:  L Poirel; T Naas; D Nicolas; L Collet; S Bellais; J D Cavallo; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

7.  Functional characterization of the antibiotic resistance reservoir in the human microflora.

Authors:  Morten O A Sommer; Gautam Dantas; George M Church
Journal:  Science       Date:  2009-08-28       Impact factor: 47.728

8.  The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form.

Authors:  I Garcia-Saez; J-D Docquier; G M Rossolini; O Dideberg
Journal:  J Mol Biol       Date:  2007-11-13       Impact factor: 5.469

9.  Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance.

Authors:  E Osano; Y Arakawa; R Wacharotayankun; M Ohta; T Horii; H Ito; F Yoshimura; N Kato
Journal:  Antimicrob Agents Chemother       Date:  1994-01       Impact factor: 5.191

10.  Antibiotic recognition by binuclear metallo-beta-lactamases revealed by X-ray crystallography.

Authors:  James Spencer; Jonathan Read; Richard B Sessions; Steven Howell; G Michael Blackburn; Steven J Gamblin
Journal:  J Am Chem Soc       Date:  2005-10-19       Impact factor: 15.419
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  24 in total

1.  Systematic analysis of metallo-β-lactamases using an automated database.

Authors:  Michael Widmann; Jürgen Pleiss; Peter Oelschlaeger
Journal:  Antimicrob Agents Chemother       Date:  2012-04-30       Impact factor: 5.191

2.  Biochemical characterization of IMP-30, a metallo-β-lactamase with enhanced activity toward ceftazidime.

Authors:  Kevin M Pegg; Eleanor M Liu; Alecander E Lacuran; Peter Oelschlaeger
Journal:  Antimicrob Agents Chemother       Date:  2013-07-08       Impact factor: 5.191

3.  The Role of Active Site Flexible Loops in Catalysis and of Zinc in Conformational Stability of Bacillus cereus 569/H/9 β-Lactamase.

Authors:  Caroline Montagner; Michaël Nigen; Olivier Jacquin; Nicolas Willet; Mireille Dumoulin; Andreas Ioannis Karsisiotis; Gordon C K Roberts; Christian Damblon; Christina Redfield; André Matagne
Journal:  J Biol Chem       Date:  2016-05-27       Impact factor: 5.157

Review 4.  B1-Metallo-β-Lactamases: Where Do We Stand?

Authors:  Maria F Mojica; Robert A Bonomo; Walter Fast
Journal:  Curr Drug Targets       Date:  2016       Impact factor: 3.465

5.  Carbamylmethyl Mercaptoacetate Thioether: A Novel Scaffold for the Development of L1 Metallo-β-lactamase Inhibitors.

Authors:  Ya-Nan Chang; Yang Xiang; Yue-Juan Zhang; Wen-Ming Wang; Cheng Chen; Peter Oelschlaeger; Ke-Wu Yang
Journal:  ACS Med Chem Lett       Date:  2017-04-24       Impact factor: 4.345

6.  QM/MM studies of monozinc β-lactamase CphA suggest that the crystal structure of an enzyme-intermediate complex represents a minor pathway.

Authors:  Shanshan Wu; Dingguo Xu; Hua Guo
Journal:  J Am Chem Soc       Date:  2010-12-07       Impact factor: 15.419

7.  Meropenem and chromacef intermediates observed in IMP-25 metallo-β-lactamase-catalyzed hydrolysis.

Authors:  Peter Oelschlaeger; Mahesh Aitha; Hao Yang; Joon S Kang; Antonia L Zhang; Eleanor M Liu; John D Buynak; Michael W Crowder
Journal:  Antimicrob Agents Chemother       Date:  2015-04-27       Impact factor: 5.191

8.  An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening.

Authors:  Pei W Thomas; Timothy Spicer; Michael Cammarata; Jennifer S Brodbelt; Peter Hodder; Walter Fast
Journal:  Bioorg Med Chem       Date:  2013-03-29       Impact factor: 3.641

9.  The sequence-activity relationship between metallo-β-lactamases IMP-1, IMP-6, and IMP-25 suggests an evolutionary adaptation to meropenem exposure.

Authors:  Eleanor M Liu; Kevin M Pegg; Peter Oelschlaeger
Journal:  Antimicrob Agents Chemother       Date:  2012-09-24       Impact factor: 5.191

10.  Elucidating the Role of Residue 67 in IMP-Type Metallo-β-Lactamase Evolution.

Authors:  Alecander E LaCuran; Kevin M Pegg; Eleanor M Liu; Christopher R Bethel; Ni Ai; William J Welsh; Robert A Bonomo; Peter Oelschlaeger
Journal:  Antimicrob Agents Chemother       Date:  2015-09-14       Impact factor: 5.191
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