| Literature DB >> 19632112 |
Nicholas A Meanwell1, Owen B Wallace, Henry Wang, Milind Deshpande, Bradley C Pearce, Ashok Trehan, Kap-Sun Yeung, Zhilei Qiu, J J Kim Wright, Brett A Robinson, Yi-Fei Gong, Hwei-Gene Heidi Wang, Timothy P Spicer, Wade S Blair, Pei-Yong Shi, Pin-fang Lin.
Abstract
1-(4-Benzoylpiperazin-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione (1a) has been characterized as an inhibitor of HIV-1 attachment that interferes with the interaction of viral gp120 with the host cell receptor CD4. In previous studies, the effect of indole substitution pattern on antiviral activity was probed. In this Letter, the effect of structural variation of the benzamide moiety is described, a study that reveals the potential or the phenyl moiety to be replaced by five-membered heterocyclic rings and a restricted tolerance for the introduction of substituents to the phenyl ring.Entities:
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Year: 2009 PMID： 19632112 DOI： 10.1016/j.bmcl.2009.07.027
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823