| Literature DB >> 19631386 |
Bernadette S Creaven1, Michael Devereux, Dariusz Karcz, Andrew Kellett, Malachy McCann, Andy Noble, Maureen Walsh.
Abstract
The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.Entities:
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Year: 2009 PMID： 19631386 DOI： 10.1016/j.jinorgbio.2009.05.017
Source DB: PubMed Journal: J Inorg Biochem ISSN： 0162-0134 Impact factor: 4.155