| Literature DB >> 19631094 |
Frans M Verduyn Lunel1, Monique A S H Mennink-Kersten, Dorien Ruegebrink, Henrich A L van der Lee, J Peter Donnelly, Nicole M A Blijlevens, Paul E Verweij.
Abstract
Invasive Candida infections are associated with a significant morbidity and mortality. Detection of circulating biomarkers has been shown to precede conventional diagnostic methods, which is important in improving outcome. We investigated the performance of multiple biomarkers using Candida antigen and anti-Candida antibody detection systems of Platelia and Serion and beta-d-glucan detection in serial serum samples from patients, treated for leukemia, with invasive candidiasis. The performance of single assays and combined detection appeared different for patients with 1 or more episodes of neutropenia and is therefore related to the phase of therapy for the underlying leukemia of the patient. These new insights may help to optimize the diagnostic strategies for the diagnosis of invasive candidiasis.Entities:
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Year: 2009 PMID： 19631094 DOI： 10.1016/j.diagmicrobio.2009.04.012
Source DB: PubMed Journal: Diagn Microbiol Infect Dis ISSN： 0732-8893 Impact factor: 2.803