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Literature DB >> 19630570

MicroRNAs in Cancer.

Ramiro Garzon¹, George A Calin, Carlo M Croce.

Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs are involved in the initiation and progression of cancer. In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer.

Entities: Disease

Mesh：

Substances：
MicroRNAs

Year: 2009 PMID： 19630570 DOI： 10.1146/annurev.med.59.053006.104707

Source DB: PubMed Journal: Annu Rev Med ISSN： 0066-4219 Impact factor: 13.739

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Cited

814 in total

1. [miR-122-5p inhibits the proliferation of melanoma cells by targeting NOP14].

Authors: Jingrong Li; Rui Zhao; Ruihua Fang; Jianqin Wang
Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2018-11-30

2. Negative feedback of miR-29 family TET1 involves in hepatocellular cancer.

Authors: Li Li Lin; Wei Wang; ZhaoYang Hu; Li Wen Wang; Jing Chang; HanGuang Qian
Journal: Med Oncol Date: 2014-11-04 Impact factor: 3.064

3. MiR-218 regulates cisplatin chemosensitivity in breast cancer by targeting BRCA1.

Authors: Xiao He; Xia Xiao; Lin Dong; Nengbin Wan; Zhengyu Zhou; Hongwu Deng; Xiefu Zhang
Journal: Tumour Biol Date: 2014-11-15

4. Down-regulation of testes-specific protease 50 induces apoptosis in human laryngocarcinoma HEp2 cells in a NF-κB-mediated pathway.

Authors: Yu-Lin Liu; Ya-Nan Sun
Journal: Mol Biol Rep Date: 2014-11-16 Impact factor: 2.316

5. Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice.

Authors: Yiming Liu; Jacob T Bailey; Mohammad Abu-Laban; Shue Li; Cong Chen; Adam B Glick; Daniel J Hayes
Journal: Biomaterials Date: 2020-06-22 Impact factor: 12.479

10. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1).

Authors: Defang Sun; Feng Yu; Yutao Ma; Ran Zhao; Xi Chen; Jie Zhu; Chen-Yu Zhang; Jiangning Chen; Junfeng Zhang
Journal: J Biol Chem Date: 2013-01-15 Impact factor: 5.157

MicroRNAs in Cancer.

1. [miR-122-5p inhibits the proliferation of melanoma cells by targeting NOP14].

2. Negative feedback of miR-29 family TET1 involves in hepatocellular cancer.

3. MiR-218 regulates cisplatin chemosensitivity in breast cancer by targeting BRCA1.

4. Down-regulation of testes-specific protease 50 induces apoptosis in human laryngocarcinoma HEp2 cells in a NF-κB-mediated pathway.

5. Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice.

6. Pax-5 Inhibits NF-κB Activity in Breast Cancer Cells Through IKKε and miRNA-155 Effectors.

Review 7. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis.

8. MicroRNA-127 is aberrantly downregulated and acted as a functional tumor suppressor in human pancreatic cancer.

9. Analysis of circulating non-coding RNAs in a non-invasive and cost-effective manner.

10. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1).