Literature DB >> 212925

Herpes simplex virus replication in pheochromocytoma cell line that responds to nerve growth factor.

L I Pizer, S U Kim, P Nystrom, V C Coates.   

Abstract

Cultured cells of neural origin (PC-12, pheochromocytoma cell line) respond to nerve growth factor (NGF) by extending neurites. These cells whether treated with NGF or not can be infected with herpes simplex virus and produce progeny virus. Viral antigens are detected on the cell surface and fusion of cells to form polykaryocytes takes place. Nucleocapsids are found within the cell nucleus and enveloped virus in a present both in the cytoplasm and extracellular space. Virus was not observed within the neurites but laterations in the neurite microtubular structure occurred after infection.

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Year:  1978        PMID: 212925     DOI: 10.1007/bf00691633

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN: 0001-6322            Impact factor:   17.088


  18 in total

Review 1.  Latent herpes simplex virus and the nervous system,.

Authors:  J G Stevens
Journal:  Curr Top Microbiol Immunol       Date:  1975       Impact factor: 4.291

2.  Latent herpetic infections following experimental viraemia.

Authors:  M L Cook; J G Stevens
Journal:  J Gen Virol       Date:  1976-04       Impact factor: 3.891

3.  Temperature-sensitive mutants of herpes simplex virus differ in the capacity to establish latent infections in mice.

Authors:  K W Lofgren; J G Stevens; H S Marsden; J H Subak-Sharpe
Journal:  Virology       Date:  1977-01       Impact factor: 3.616

4.  Synthesis, storage and release of acetylcholine by a noradrenergic pheochromocytoma cell line.

Authors:  L A Greene; G Rein
Journal:  Nature       Date:  1977-07-28       Impact factor: 49.962

5.  Maintenance of latent herpetic infection: an apparent role for anti-viral IgG.

Authors:  J G Stevens; M L Cook
Journal:  J Immunol       Date:  1974-12       Impact factor: 5.422

6.  Latent herpes simplex virus in spinal ganglia of mice.

Authors:  J G Stevens; M L Cook
Journal:  Science       Date:  1971-08-27       Impact factor: 47.728

7.  Ultrastructural aspects of herpes simplex virus infection in organized cultures of mammalian nervous tissue.

Authors:  J E Leestma; M B Bornstein; R D Sheppard; L A Feldman
Journal:  Lab Invest       Date:  1969-01       Impact factor: 5.662

8.  Growth of herpes simplex virus in transformed glial and neuronal cells in tissue culture: ultrastructural studies.

Authors:  J Schwartz; T S Elizan
Journal:  J Neuropathol Exp Neurol       Date:  1973-04       Impact factor: 3.685

9.  Comparative effects of herpes simplex virus types 1 and 2 in organotypic cultures of mouse dorsal root ganglion.

Authors:  W O Whetsell; J Schwartz; T S Elizan
Journal:  J Neuropathol Exp Neurol       Date:  1977-05       Impact factor: 3.685

10.  Herpes simplex virus-host cell relationships in organized cultures of mammalian nerve tissues.

Authors:  L A Feldman; R D Sheppard; M B Bornstein
Journal:  J Virol       Date:  1968-06       Impact factor: 5.103

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  2 in total

1.  Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro.

Authors:  C L Wilcox; E M Johnson
Journal:  J Virol       Date:  1987-07       Impact factor: 5.103

2.  Herpesvirus glycoprotein synthesis and insertion into plasma membranes.

Authors:  M L Peake; P Nystrom; L I Pizer
Journal:  J Virol       Date:  1982-05       Impact factor: 5.103

  2 in total

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