INTRODUCTION: Disorders of the reproductive system and menstrual abnormalities often associated with loss of libido and inability to reach orgasm are common in adults of both sexes with an end-stage renal disease. These symptoms may significantly contribute to depression and reduce the sexual activity of women. AIM: To determine if sexual function, as well as hormonal status, improves after kidney transplantation, comparing a group of pre-menopausal women during dialysis and after a successful renal transplantation. METHODS: We enrolled 58 women that received kidney transplantation. Patients included were 18-45 years old, on hemodialysis for more than 6 months following a fully functioning kidney transplantation, and on a stable corticosteroids immunosuppressive regimen for at least 6 months. All women underwent a general and urogynecological examination, a hormonal profile determination, and filled out the Female Sexual Function Index (FSFI) and a Beck Depression Inventory questionnaire administered during dialysis and 12 months after transplantation. MAIN OUTCOME MEASURES: We evaluated the prevalence of Female Sexual Dysfunction according to the FSFI cutoff points, sexual hormonal status, and menstrual status during dialysis and 12 months after kidney transplantation. RESULTS: Nineteen out of 58 women left the study prematurely. Thirty-nine women (mean age 36 +/- 5.9 years) completed the study. A total of 74% of the patients had menstrual disturbances during dialysis, as opposed to 45% after transplantation (P < 0.001). Sixteen out of 39 (41%) patients acknowledged having an active sexual life during dialysis. Thirty-four out of 39 (88%) transplanted patients acknowledged having an active sexual life (Fischer's exact test P = 0.000039). The hormonal profile and FSFI results improved significantly after transplantation. CONCLUSION: This study demonstrates that a successful transplantation should improve the sexual life in women with chronic renal failure.
INTRODUCTION: Disorders of the reproductive system and menstrual abnormalities often associated with loss of libido and inability to reach orgasm are common in adults of both sexes with an end-stage renal disease. These symptoms may significantly contribute to depression and reduce the sexual activity of women. AIM: To determine if sexual function, as well as hormonal status, improves after kidney transplantation, comparing a group of pre-menopausal women during dialysis and after a successful renal transplantation. METHODS: We enrolled 58 women that received kidney transplantation. Patients included were 18-45 years old, on hemodialysis for more than 6 months following a fully functioning kidney transplantation, and on a stable corticosteroids immunosuppressive regimen for at least 6 months. All women underwent a general and urogynecological examination, a hormonal profile determination, and filled out the Female Sexual Function Index (FSFI) and a Beck Depression Inventory questionnaire administered during dialysis and 12 months after transplantation. MAIN OUTCOME MEASURES: We evaluated the prevalence of Female Sexual Dysfunction according to the FSFI cutoff points, sexual hormonal status, and menstrual status during dialysis and 12 months after kidney transplantation. RESULTS: Nineteen out of 58 women left the study prematurely. Thirty-nine women (mean age 36 +/- 5.9 years) completed the study. A total of 74% of the patients had menstrual disturbances during dialysis, as opposed to 45% after transplantation (P < 0.001). Sixteen out of 39 (41%) patients acknowledged having an active sexual life during dialysis. Thirty-four out of 39 (88%) transplanted patients acknowledged having an active sexual life (Fischer's exact test P = 0.000039). The hormonal profile and FSFI results improved significantly after transplantation. CONCLUSION: This study demonstrates that a successful transplantation should improve the sexual life in women with chronic renal failure.
Authors: Maria K Mor; Mary Ann Sevick; Anne Marie Shields; Jamie A Green; Paul M Palevsky; Robert M Arnold; Michael J Fine; Steven D Weisbord Journal: Clin J Am Soc Nephrol Date: 2013-12-19 Impact factor: 8.237
Authors: Giovanni F M Strippoli; Mariacristina Vecchio; Suetonia Palmer; Giorgia De Berardis; Jonathan Craig; Giuseppe Lucisano; David Johnson; Fabio Pellegrini; Antonio Nicolucci; Michela Sciancalepore; Valeria Saglimbene; Letizia Gargano; Carmen Bonifati; Marinella Ruospo; Sankar D Navaneethan; Vincenzo Montinaro; Paul Stroumza; Marianna Zsom; Mariatta Torok; Eduardo Celia; Ruben Gelfman; Anna Bednarek-Skublewska; Jan Dulawa; Giusi Graziano; Giorgio Gentile; Juan Nin Ferrari; Antonio Santoro; Annalisa Zucchelli; Giorgio Triolo; Stefano Maffei; Jörgen Hegbrant; Charlotta Wollheim; Salvatore De Cosmo; Valeria M Manfreda Journal: Clin J Am Soc Nephrol Date: 2012-04-05 Impact factor: 8.237
Authors: Adam Bass; Sofia B Ahmed; Scott Klarenbach; Bruce Culleton; Brenda R Hemmelgarn; Braden Manns Journal: BMC Nephrol Date: 2012-07-26 Impact factor: 2.388