| Literature DB >> 19626456 |
Xianghui Chen1, Kai Cui, Jiancheng Xiu, Huanbing Lin, Yi Lao, Biying Zhou, Feixue Liang, Daogang Zha, Jianping Bin, Yili Liu.
Abstract
To test the feasibility and accuracy of myocardial contrast echocardiography (MCE) for predicting infarct size (IS) in a rat model of myocardial infarction (MI) and to compare a simplified single plane-based measurement of IS with the conventional three plane-based approach. Fifty male SD rats underwent left anterior descending artery ligation and were evaluated by MCE 8 h post MI. IS was calculated by the single and three plane-based approaches, compared to that determined by triphenyltetrazolium chloride (TTC) staining method. Simplified single plane-based MCE approach and TTC method showed similar IS values (38.48 +/- 16.80% vs. 35.72 +/- 15.33%, P > 0.05) and presented a favorable positive correlation (r = 0.851, P < 0.001). IS values derived from simplified single plane-based approach was also highly significantly correlated with that by the conventional MCE method (r = 0.973, P < 0.001). Bland-Altman plots also displayed satisfactory agreement between them. MCE was validated as a novel technique to quantify infarct area in rats with MI. A single measurement at the mid-papillary muscle level may become a simple, efficient and reliable approach for in vivo IS assessment.Entities:
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Year: 2009 PMID： 19626456 DOI： 10.1007/s10554-009-9474-x
Source DB: PubMed Journal: Int J Cardiovasc Imaging ISSN： 1569-5794 Impact factor: 2.357