[Individualized prevention of type 2 diabetes].

The global estimated prevalence of diabetes today is 246 million people. By 2025, the figure is expected to rise to 380 million. In Germany about 7 to 8% of the population is diagnosed with diabetes. However, there are a large proportion of people with unknown diabetes and the total number of subjects with diabetes is estimated at 7 to 8 million, indicating that every tenth individual is affected by the disease. Several recent studies unanimously revealed that it is possible to prevent type 2 diabetes. Particularly lifestyle intervention showed promising results. However, there is large variability in the effect of the intervention, and people with a good response (responders) and with a low response (non-responders) can be identified. Meanwhile, several genetic and phenotypic markers have been identified, which can help predict the success of the lifestyle intervention, allowing for a more effective individualized prevention of type 2 diabetes.