OBJECTIVE: Using neuroimaging, we analyzed the nature of extensive brain lesions in five anti-aquaporin-4 (AQP4) antibody-positive patients with neuromyelitis optica spectrum disorders. RESULTS: Extensive brain lesions involved white matter in three, and basal ganglia and corpus callosum in one each. Four patients showed high diffusivity on apparent diffusion coefficient maps and three demonstrated increased choline/creatine ratios and decreased N-acetyl-aspartate/creatine ratios on (1)H-magnetic resonance spectroscopy. These findings suggested that the lesions were vasogenic edema associated with inflammation. Unusual brain symptoms associated with such lesions included recurrent limbic encephalitis, parkinsonism, and coma. CONCLUSION: Anti-AQP4 antibody is considered to be associated with the neuroimaging appearances of vasogenic edema.
OBJECTIVE: Using neuroimaging, we analyzed the nature of extensive brain lesions in five anti-aquaporin-4 (AQP4) antibody-positive patients with neuromyelitis optica spectrum disorders. RESULTS: Extensive brain lesions involved white matter in three, and basal ganglia and corpus callosum in one each. Four patients showed high diffusivity on apparent diffusion coefficient maps and three demonstrated increased choline/creatine ratios and decreased N-acetyl-aspartate/creatine ratios on (1)H-magnetic resonance spectroscopy. These findings suggested that the lesions were vasogenic edema associated with inflammation. Unusual brain symptoms associated with such lesions included recurrent limbic encephalitis, parkinsonism, and coma. CONCLUSION: Anti-AQP4 antibody is considered to be associated with the neuroimaging appearances of vasogenic edema.
Authors: Mkael Symmonds; Niranjanan Nirmalananthan; Graham P Taylor; Leslie R Bridges; Frederick Schon Journal: J Neurol Date: 2012-08-24 Impact factor: 4.849
Authors: Ho Jin Kim; Friedemann Paul; Marco A Lana-Peixoto; Silvia Tenembaum; Nasrin Asgari; Jacqueline Palace; Eric C Klawiter; Douglas K Sato; Jérôme de Seze; Jens Wuerfel; Brenda L Banwell; Pablo Villoslada; Albert Saiz; Kazuo Fujihara; Su-Hyun Kim Journal: Neurology Date: 2015-02-18 Impact factor: 9.910
Authors: Yeliz Pekcevik; Charles H Mitchell; Maureen A Mealy; Gunes Orman; In H Lee; Scott D Newsome; Carol B Thompson; Carlos A Pardo; Peter A Calabresi; Michael Levy; Izlem Izbudak Journal: Mult Scler Date: 2015-07-24 Impact factor: 6.312