Literature DB >> 19622346

Phostensin caps to the pointed end of actin filaments and modulates actin dynamics.

Ning-Sheng Lai1, Tzu-Fan Wang, Shiu-Lan Wang, Chun-Yu Chen, Jia-yi Yen, Hsien-lu Huang, Chin Li, Kuang-Yung Huang, Su-Qin Liu, Ta-Hsien Lin, Hsien-bin Huang.   

Abstract

Phostensin, a protein phosphatase 1 F-actin cytoskeleton targeting subunit encoded by KIAA1949, consists of 165 amino acids and is located between HLA-C and HLA-E gene clusters on human chromosome 6. In this current study, we characterized the biochemical functions of phostensin. Actin dynamics assays using gelsolin-actin seeds showed that phostensin decreases the elongation and depolymerization rates of actin filament pointed ends. The feature of phostensin that binds to the pointed ends of actin filaments was observed through fluorescent single filament binding assay. Taken together, our results suggested that phostensin is an actin filament pointed end-capping protein that is capable of modulating actin dynamics.

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Year:  2009        PMID： 19622346     DOI： 10.1016/j.bbrc.2009.07.086

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

1.  Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79.

Authors:  Atteeq Ur Rehman; Robert J Morell; Inna A Belyantseva; Shahid Y Khan; Erich T Boger; Mohsin Shahzad; Zubair M Ahmed; Saima Riazuddin; Shaheen N Khan; Sheikh Riazuddin; Thomas B Friedman
Journal:  Am J Hum Genet       Date:  2010-02-18       Impact factor: 11.025

Review 2.  Actin in hair cells and hearing loss.

Authors:  Meghan C Drummond; Inna A Belyantseva; Karen H Friderici; Thomas B Friedman
Journal:  Hear Res       Date:  2011-12-13       Impact factor: 3.208

3.  Immunolocalization of phostensin in lymphatic cells and tissues.

Authors:  Yu-Shan Lin; Kuang-Yung Huang; Tzu-Fan Wang; Hsien-lu Huang; Hui-Chun Yu; Jia-yi Yen; Shih-hui Hung; Su-Qin Liu; Ning-Sheng Lai; Hsien-bin Huang
Journal:  J Histochem Cytochem       Date:  2011-08       Impact factor: 2.479

4.  CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI.

Authors:  Felipe T Salles; Leonardo R Andrade; Soichi Tanda; M'hamed Grati; Kathleen L Plona; Leona H Gagnon; Kenneth R Johnson; Bechara Kachar; Mark A Berryman
Journal:  Cytoskeleton (Hoboken)       Date:  2013-12-10

5.  Undetectable and Decreased Expression of KIAA1949 (Phostensin) Encoded on Chromosome 6p21.33 in Human Breast Cancers Revealed by Transcriptome Analysis.

Authors:  Yan A Su; Jun Yang; Lian Tao; Hein Nguyen; Ping He
Journal:  J Cancer       Date:  2010-06-21       Impact factor: 4.207

6.  The Actin-Binding Protein PPP1r18 Regulates Maturation, Actin Organization, and Bone Resorption Activity of Osteoclasts.

Authors:  Takuma Matsubara; Shoichiro Kokabu; Chihiro Nakatomi; Masayuki Kinbara; Toshihiro Maeda; Mitsuhiro Yoshizawa; Hisataka Yasuda; Teruko Takano-Yamamoto; Roland Baron; Eijiro Jimi
Journal:  Mol Cell Biol       Date:  2018-01-29       Impact factor: 4.272

Review 7.  Next-generation sequencing in genetic hearing loss.

Authors:  Denise Yan; Mustafa Tekin; Susan H Blanton; Xue Zhong Liu
Journal:  Genet Test Mol Biomarkers       Date:  2013-06-05

8.  Mutations in TPRN cause a progressive form of autosomal-recessive nonsyndromic hearing loss.

Authors:  Yun Li; Esther Pohl; Redouane Boulouiz; Margit Schraders; Gudrun Nürnberg; Majida Charif; Ronald J C Admiraal; Simon von Ameln; Ingelore Baessmann; Mostafa Kandil; Joris A Veltman; Peter Nürnberg; Christian Kubisch; Abdelhamid Barakat; Hannie Kremer; Bernd Wollnik
Journal:  Am J Hum Genet       Date:  2010-02-18       Impact factor: 11.025

9.  Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.

Authors:  Dinu Antony; Anita Becker-Heck; Maimoona A Zariwala; Miriam Schmidts; Alexandros Onoufriadis; Mitra Forouhan; Robert Wilson; Theresa Taylor-Cox; Ann Dewar; Claire Jackson; Patricia Goggin; Niki T Loges; Heike Olbrich; Martine Jaspers; Mark Jorissen; Margaret W Leigh; Whitney E Wolf; M Leigh Anne Daniels; Peadar G Noone; Thomas W Ferkol; Scott D Sagel; Margaret Rosenfeld; Andrew Rutman; Abhijit Dixit; Christopher O'Callaghan; Jane S Lucas; Claire Hogg; Peter J Scambler; Richard D Emes; Eddie M K Chung; Amelia Shoemark; Michael R Knowles; Heymut Omran; Hannah M Mitchison
Journal:  Hum Mutat       Date:  2013-02-11       Impact factor: 4.878

10.  Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein.

Authors:  Tony Ferrar; Delphine Chamousset; Veerle De Wever; Mhairi Nimick; Jens Andersen; Laura Trinkle-Mulcahy; Greg B G Moorhead
Journal:  Biol Open       Date:  2011-11-24       Impact factor: 2.422
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