Literature DB >> 19620980

Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.

Christine F Skibola1, Paige M Bracci, Eran Halperin, Lucia Conde, David W Craig, Luz Agana, Kelly Iyadurai, Nikolaus Becker, Angela Brooks-Wilson, John D Curry, John J Spinelli, Elizabeth A Holly, Jacques Riby, Luoping Zhang, Alexandra Nieters, Martyn T Smith, Kevin M Brown.   

Abstract

We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).

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Mesh：

Year:  2009        PMID： 19620980      PMCID： PMC2823809          DOI： 10.1038/ng.419

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  12 in total

1.  Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics.

Authors:  Keyan Salari; Shweta Choudhry; Hua Tang; Mariam Naqvi; Denise Lind; Pedro C Avila; Natasha E Coyle; Ngim Ung; Sylvette Nazario; Jesus Casal; Alfonso Torres-Palacios; Suzanne Clark; Angie Phong; Ivan Gomez; Henry Matallana; Eliseo J Pérez-Stable; Mark D Shriver; Pui-Yan Kwok; Dean Sheppard; William Rodriguez-Cintron; Neil J Risch; Esteban González Burchard; Elad Ziv
Journal:  Genet Epidemiol       Date:  2005-07       Impact factor: 2.135

2.  Organochlorines and risk of non-Hodgkin lymphoma.

Authors:  John J Spinelli; Carmen H Ng; Jean-Philippe Weber; Joseph M Connors; Randy D Gascoyne; Agnes S Lai; Angela R Brooks-Wilson; Nhu D Le; Brian R Berry; Richard P Gallagher
Journal:  Int J Cancer       Date:  2007-12-15       Impact factor: 7.396

3.  Multimarker analysis and imputation of multiple platform pooling-based genome-wide association studies.

Authors:  Nils Homer; Waibhav D Tembe; Szabolcs Szelinger; Margot Redman; Dietrich A Stephan; John V Pearson; Stanley F Nelson; David Craig
Journal:  Bioinformatics       Date:  2008-07-10       Impact factor: 6.937

4.  Large-scale analysis of the human and mouse transcriptomes.

Authors:  Andrew I Su; Michael P Cooke; Keith A Ching; Yaron Hakak; John R Walker; Tim Wiltshire; Anthony P Orth; Raquel G Vega; Lisa M Sapinoso; Aziz Moqrich; Ardem Patapoutian; Garret M Hampton; Peter G Schultz; John B Hogenesch
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

5.  Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.

Authors:  Rajan P Nair; Philip E Stuart; Ioana Nistor; Ravi Hiremagalore; Nicholas V C Chia; Stefan Jenisch; Michael Weichenthal; Gonçalo R Abecasis; Henry W Lim; Enno Christophers; John J Voorhees; James T Elder
Journal:  Am J Hum Genet       Date:  2006-03-31       Impact factor: 11.025

6.  Etiologic heterogeneity among non-Hodgkin lymphoma subtypes.

Authors:  Lindsay M Morton; Sophia S Wang; Wendy Cozen; Martha S Linet; Nilanjan Chatterjee; Scott Davis; Richard K Severson; Joanne S Colt; Mohammad A Vasef; Nathaniel Rothman; Aaron Blair; Leslie Bernstein; Amanda J Cross; Anneclaire J De Roos; Eric A Engels; David W Hein; Deirdre A Hill; Linda E Kelemen; Unhee Lim; Charles F Lynch; Maryjean Schenk; Sholom Wacholder; Mary H Ward; Shelia Hoar Zahm; Stephen J Chanock; James R Cerhan; Patricia Hartge
Journal:  Blood       Date:  2008-09-16       Impact factor: 22.113

7.  Population-based study of lymphoma in Germany: rationale, study design and first results.

Authors:  Nikolaus Becker; Evelin Deeg; Alexandra Nieters
Journal:  Leuk Res       Date:  2004-07       Impact factor: 3.156

Review 8.  Genetic susceptibility to lymphoma.

Authors:  Christine F Skibola; John D Curry; Alexandra Nieters
Journal:  Haematologica       Date:  2007-07       Impact factor: 9.941

9.  Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma.

Authors:  Christine F Skibola; Elizabeth A Holly; Matthew S Forrest; Alan Hubbard; Paige M Bracci; Danica R Skibola; Christine Hegedus; Martyn T Smith
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2004-05       Impact factor: 4.254

10.  Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.

Authors:  Christine F Skibola; Paige M Bracci; Eran Halperin; Alexandra Nieters; Alan Hubbard; Randi A Paynter; Danica R Skibola; Luz Agana; Nikolaus Becker; Patrick Tressler; Matthew S Forrest; Sriram Sankararaman; Lucia Conde; Elizabeth A Holly; Martyn T Smith
Journal:  PLoS One       Date:  2008-06-30       Impact factor: 3.240
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  84 in total

1.  Multi-locus HLA class I and II allele and haplotype associations with follicular lymphoma.

Authors:  C F Skibola; N K Akers; L Conde; M Ladner; S K Hawbecker; F Cohen; F Ribas; H A Erlich; D Goodridge; E A Trachtenberg; M T Smith; P M Bracci
Journal:  Tissue Antigens       Date:  2012-02-02

2.  Familial Aspects of Chronic Lymphocytic Leukemia, Monoclonal B-Cell Lymphocytosis (MBL), and Related Lymphomas.

Authors:  Lynn R Goldin; Ola Landgren; Gerald E Marti; Neil E Caporaso
Journal:  European J Clin Med Oncol       Date:  2010-02

Review 3.  Familial predisposition and genetic risk factors for lymphoma.

Authors:  James R Cerhan; Susan L Slager
Journal:  Blood       Date:  2015-09-24       Impact factor: 22.113

4.  eALPS: estimating abundance levels in pooled sequencing using available genotyping data.

Authors:  Itamar Eskin; Farhad Hormozdiari; Lucia Conde; Jacques Riby; Christine F Skibola; Eleazar Eskin; Eran Halperin
Journal:  J Comput Biol       Date:  2013-10-21       Impact factor: 1.479

5.  Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies.

Authors:  Qing Lan; Sophia S Wang; Idan Menashe; Bruce Armstrong; Yawei Zhang; Patricia Hartge; Mark P Purdue; Theodore R Holford; Lindsay M Morton; Anne Kricker; James R Cerhan; Andrew Grulich; Wendy Cozen; Shelia H Zahm; Meredith Yeager; Claire M Vajdic; Maryjean Schenk; Brian Leaderer; Jeff Yuenger; Richard K Severson; Nilanjan Chatterjee; Stephen J Chanock; Tongzhang Zheng; Nathaniel Rothman
Journal:  Br J Haematol       Date:  2011-03-21       Impact factor: 6.998

Review 6.  Host genetics in follicular lymphoma.

Authors:  James R Cerhan
Journal:  Best Pract Res Clin Haematol       Date:  2011-05-05       Impact factor: 3.020

7.  PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium.

Authors:  Alexandra Nieters; Lucia Conde; Susan L Slager; Angela Brooks-Wilson; Lindsay Morton; Danica R Skibola; Anne J Novak; Jacques Riby; Stephen M Ansell; Eran Halperin; Tait D Shanafelt; Luz Agana; Alice H Wang; Anneclaire J De Roos; Richard K Severson; Wendy Cozen; John Spinelli; Katja Butterbach; Nikolaus Becker; Silvia de Sanjose; Yolanda Benavente; Pierluigi Cocco; Anthony Staines; Marc Maynadié; Lenka Foretova; Paolo Boffetta; Paul Brennan; Qing Lan; Yawei Zhang; Tongzhang Zheng; Mark Purdue; Bruce Armstrong; Anne Kricker; Claire M Vajdic; Andrew Grulich; Martyn T Smith; Paige M Bracci; Stephen J Chanock; Patricia Hartge; James R Cerhan; Sophia S Wang; Nathaniel Rothman; Christine F Skibola
Journal:  Blood       Date:  2012-10-09       Impact factor: 22.113

8.  Rare variant association testing under low-coverage sequencing.

Authors:  Oron Navon; Jae Hoon Sul; Buhm Han; Lucia Conde; Paige M Bracci; Jacques Riby; Christine F Skibola; Eleazar Eskin; Eran Halperin
Journal:  Genetics       Date:  2013-05-01       Impact factor: 4.562

9.  Genome-wide association studies in cancer--current and future directions.

Authors:  Charles C Chung; Wagner C S Magalhaes; Jesus Gonzalez-Bosquet; Stephen J Chanock
Journal:  Carcinogenesis       Date:  2009-11-11       Impact factor: 4.944

10.  Integrating GWAS and expression data for functional characterization of disease-associated SNPs: an application to follicular lymphoma.

Authors:  Lucia Conde; Paige M Bracci; Rhea Richardson; Stephen B Montgomery; Christine F Skibola
Journal:  Am J Hum Genet       Date:  2012-12-13       Impact factor: 11.025
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