Literature DB >> 1375703

Specific MR imaging of human lymphocytes by monoclonal antibody-guided dextran-magnetite particles.

J W Bulte1, Y Hoekstra, R L Kamman, R L Magin, A G Webb, R W Briggs, K G Go, C E Hulstaert, S Miltenyi, T H The.   

Abstract

Human lymphocytes were labeled with biotinylated anti-lymphocyte-directed monoclonal antibodies, to which streptavidin and subsequently biotinylated dextran-magnetite particles were coupled. This labeling resulted in a strong and selective negative contrast enhancement of lymphocyte suspensions at 2.0 T, caused predominantly by the specific increase of R2 with a small but significant specific increase of R1. The R1 was found to decrease with increasing field strength. The immunolabeling procedure described here may be used for the selective signal depletion of target cells in MR imaging.

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Year:  1992        PMID： 1375703     DOI： 10.1002/mrm.1910250115

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  30 in total

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