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Literature DB >> 19619641

The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery.

Chen Davidovich¹, Matthew Belousoff, Anat Bashan, Ada Yonath.

Abstract

Structural analysis supported by biochemical, mutagenesis and computational evidence, revealed that the contemporary ribosome's active site is a universal symmetrical pocket made of ribosomal RNA. This pocket seems to be the remnant of the proto-ribosome, a dimeric RNA assembly evolved by gene duplication, capable of autonomously catalyzing peptide bond formation and non-coded amino acid polymerization.

Mesh：

Substances：
Peptides

Year: 2009 PMID： 19619641 DOI： 10.1016/j.resmic.2009.07.004

Source DB: PubMed Journal: Res Microbiol ISSN： 0923-2508 Impact factor: 3.992

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Cited

25 in total

1. An exit cavity was crucial to the polymerase activity of the early ribosome.

Authors: George E Fox; Quyen Tran; Ada Yonath
Journal: Astrobiology Date: 2011-12-22 Impact factor: 4.335

2. The transition from noncoded to coded protein synthesis: did coding mRNAs arise from stability-enhancing binding partners to tRNA?

Authors: Harold Stephen Bernhardt; Warren Perry Tate
Journal: Biol Direct Date: 2010-04-09 Impact factor: 4.540

9. Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes.

Authors: Rasa Rakauskaite; Jonathan D Dinman
Journal: RNA Date: 2011-03-25 Impact factor: 4.942

10. Ancient Systems of Sodium/Potassium Homeostasis as Predecessors of Membrane Bioenergetics.

Authors: D V Dibrova; M Y Galperin; E V Koonin; A Y Mulkidjanian
Journal: Biochemistry (Mosc) Date: 2015-05 Impact factor: 2.487

The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery.

1. An exit cavity was crucial to the polymerase activity of the early ribosome.

2. The transition from noncoded to coded protein synthesis: did coding mRNAs arise from stability-enhancing binding partners to tRNA?

Review 3. Origin and evolution of the ribosome.

4. Protoribosome by quantum kernel energy method.

Review 5. Large facilities and the evolving ribosome, the cellular machine for genetic-code translation.

6. The Proto-Ribosome: an ancient nano-machine for peptide bond formation.

7. Origin of the 16S Ribosomal Molecule from Ancestor tRNAs.

8. Origins and emergent evolution of life: the colloid microsphere hypothesis revisited.

9. Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes.

10. Ancient Systems of Sodium/Potassium Homeostasis as Predecessors of Membrane Bioenergetics.