Literature DB >> 19616761

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Nicolas Legrand1, Alexander Ploss, Rudi Balling, Pablo D Becker, Chiara Borsotti, Nicolas Brezillon, Jennifer Debarry, Ype de Jong, Hongkui Deng, James P Di Santo, Stephanie Eisenbarth, Elizabeth Eynon, Richard A Flavell, Carlos A Guzman, Nicholas D Huntington, Dina Kremsdorf, Michael P Manns, Markus G Manz, Jean-Jacques Mention, Michael Ott, Chozhavendan Rathinam, Charles M Rice, Anthony Rongvaux, Sean Stevens, Hergen Spits, Hélène Strick-Marchand, Hitoshi Takizawa, Anja U van Lent, Chengyan Wang, Kees Weijer, Tim Willinger, Patrick Ziegler.   

Abstract

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

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Year:  2009        PMID： 19616761      PMCID： PMC7038630          DOI： 10.1016/j.chom.2009.06.006

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  15 in total

1.  Development of a human adaptive immune system in cord blood cell-transplanted mice.

Authors:  Elisabetta Traggiai; Laurie Chicha; Luca Mazzucchelli; Lucio Bronz; Jean-Claude Piffaretti; Antonio Lanzavecchia; Markus G Manz
Journal:  Science       Date:  2004-04-02       Impact factor: 47.728

Review 2.  Humanized mice in translational biomedical research.

Authors:  Leonard D Shultz; Fumihiko Ishikawa; Dale L Greiner
Journal:  Nat Rev Immunol       Date:  2007-02       Impact factor: 53.106

3.  Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.

Authors:  Michael W Melkus; Jacob D Estes; Angela Padgett-Thomas; Joel Gatlin; Paul W Denton; Florence A Othieno; Anja K Wege; Ashley T Haase; J Victor Garcia
Journal:  Nat Med       Date:  2006-10-22       Impact factor: 53.440

4.  NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.

Authors:  Mamoru Ito; Hidefumi Hiramatsu; Kimio Kobayashi; Kazutomo Suzue; Mariko Kawahata; Kyoji Hioki; Yoshito Ueyama; Yoshio Koyanagi; Kazuo Sugamura; Kohichiro Tsuji; Toshio Heike; Tatsutoshi Nakahata
Journal:  Blood       Date:  2002-11-01       Impact factor: 22.113

Review 5.  Chimpanzee models for human disease and immunobiology.

Authors:  E A Muchmore
Journal:  Immunol Rev       Date:  2001-10       Impact factor: 12.988

Review 6.  Experimental models to study development and function of the human immune system in vivo.

Authors:  Nicolas Legrand; Kees Weijer; Hergen Spits
Journal:  J Immunol       Date:  2006-02-15       Impact factor: 5.422

7.  Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells.

Authors:  Ramon Gimeno; Kees Weijer; Arie Voordouw; Christel H Uittenbogaart; Nicolas Legrand; Nuno L Alves; Erwin Wijnands; Bianca Blom; Hergen Spits
Journal:  Blood       Date:  2004-08-19       Impact factor: 22.113

8.  Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice.

Authors:  Hisaya Azuma; Nicole Paulk; Aarati Ranade; Craig Dorrell; Muhsen Al-Dhalimy; Ewa Ellis; Stephen Strom; Mark A Kay; Milton Finegold; Markus Grompe
Journal:  Nat Biotechnol       Date:  2007-07-29       Impact factor: 54.908

9.  Human-hemato-lymphoid-system mice: opportunities and challenges.

Authors:  Markus G Manz
Journal:  Immunity       Date:  2007-05       Impact factor: 31.745

10.  Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice.

Authors:  Paul W Denton; Jacob D Estes; Zhifeng Sun; Florence A Othieno; Bangdong L Wei; Anja K Wege; Daniel A Powell; Deborah Payne; Ashley T Haase; J Victor Garcia
Journal:  PLoS Med       Date:  2008-01-15       Impact factor: 11.069
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  106 in total

1.  Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles.

Authors:  Sandra Ciesek; Sandra Westhaus; Melanie Wicht; Ilka Wappler; Sylvana Henschen; Christoph Sarrazin; Nabila Hamdi; Ahmed I Abdelaziz; Christian P Strassburg; Heiner Wedemeyer; Michael P Manns; Thomas Pietschmann; Thomas von Hahn
Journal:  J Virol       Date:  2011-06-01       Impact factor: 5.103

2.  Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice.

Authors:  Jiehua Zhou; C Preston Neff; Xiaoxuan Liu; Jane Zhang; Haitang Li; David D Smith; Piotr Swiderski; Tawfik Aboellail; Yuanyu Huang; Quan Du; Zicai Liang; Ling Peng; Ramesh Akkina; John J Rossi
Journal:  Mol Ther       Date:  2011-09-27       Impact factor: 11.454

3.  New horizons for studying human hepatotropic infections.

Authors:  Ype P de Jong; Charles M Rice; Alexander Ploss
Journal:  J Clin Invest       Date:  2010-02-22       Impact factor: 14.808

Review 4.  Preclinical mouse cancer models: a maze of opportunities and challenges.

Authors:  Chi-Ping Day; Glenn Merlino; Terry Van Dyke
Journal:  Cell       Date:  2015-09-24       Impact factor: 41.582

5.  Malaria: The vector as protector.

Authors:  Andrew F Read; Nicole Mideo
Journal:  Nature       Date:  2013-05-29       Impact factor: 49.962

Review 6.  Progress in the development of vaccines for hepatitis C virus infection.

Authors:  Faezeh Ghasemi; Sina Rostami; Zahra Meshkat
Journal:  World J Gastroenterol       Date:  2015-11-14       Impact factor: 5.742

7.  Human-animal chimeras for vaccine development: an endangered species or opportunity for the developing world?

Authors:  Anant Bhan; Peter A Singer; Abdallah S Daar
Journal:  BMC Int Health Hum Rights       Date:  2010-05-19

8.  Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations.

Authors:  Ryan M O'Connell; Alejandro B Balazs; Dinesh S Rao; Christine Kivork; Lili Yang; David Baltimore
Journal:  PLoS One       Date:  2010-08-06       Impact factor: 3.240

9.  Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.

Authors:  Pablo D Becker; Nicolas Legrand; Caroline M M van Geelen; Miriam Noerder; Nicholas D Huntington; Annick Lim; Etsuko Yasuda; Sean A Diehl; Ferenc A Scheeren; Michael Ott; Kees Weijer; Heiner Wedemeyer; James P Di Santo; Tim Beaumont; Carlos A Guzman; Hergen Spits
Journal:  PLoS One       Date:  2010-10-04       Impact factor: 3.240

Review 10.  Towards a small animal model for hepatitis C.

Authors:  Alexander Ploss; Charles M Rice
Journal:  EMBO Rep       Date:  2009-10-16       Impact factor: 8.807
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