Literature DB >> 19616430

Design of selective Cathepsin inhibitors.

Paul A Bethel1, Stefan Gerhardt, Emma V Jones, Peter W Kenny, Galith I Karoutchi, Andrew D Morley, Keith Oldham, Neil Rankine, Martin Augustin, Stephan Krapp, Hannes Simader, Stefan Steinbacher.   

Abstract

A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors.

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Year:  2009        PMID： 19616430     DOI： 10.1016/j.bmcl.2009.06.090

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Specialized roles for cysteine cathepsins in health and disease.

Authors:  Jochen Reiser; Brian Adair; Thomas Reinheckel
Journal:  J Clin Invest       Date:  2010-10-01       Impact factor: 14.808

2.  The influence of hydrogen bonding on partition coefficients.

Authors:  Nádia Melo Borges; Peter W Kenny; Carlos A Montanari; Igor M Prokopczyk; Jean F R Ribeiro; Josmar R Rocha; Geraldo Rodrigues Sartori
Journal:  J Comput Aided Mol Des       Date:  2017-01-04       Impact factor: 3.686

3.  Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.

Authors:  J Dennemärker; T Lohmüller; J Mayerle; M Tacke; M M Lerch; L M Coussens; C Peters; T Reinheckel
Journal:  Oncogene       Date:  2009-12-21       Impact factor: 9.867

4.  Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives.

Authors:  Mauricio Angel Vega-Teijido; Sarah El Chamy Maluf; Camila Ramalho Bonturi; Julio Ricardo Sambrano; Oscar N Ventura
Journal:  J Mol Model       Date:  2014-06-01       Impact factor: 1.810

5.  Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors.

Authors:  Leandro A A Avelar; Cristian D Camilo; Sérgio de Albuquerque; William B Fernandes; Cristiana Gonçalez; Peter W Kenny; Andrei Leitão; James H McKerrow; Carlos A Montanari; Erika V Meñaca Orozco; Jean F R Ribeiro; Josmar R Rocha; Fabiana Rosini; Marta E Saidel
Journal:  PLoS Negl Trop Dis       Date:  2015-07-14

Review 6.  Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors.

Authors:  Marton Siklos; Manel BenAissa; Gregory R J Thatcher
Journal:  Acta Pharm Sin B       Date:  2015-09-26       Impact factor: 11.413

7.  Natural Products as New Treatment Options for Trichomoniasis: A Molecular Docking Investigation.

Authors:  Mary Snow Setzer; Kendall G Byler; Ifedayo Victor Ogungbe; William N Setzer
Journal:  Sci Pharm       Date:  2017-01-27
  7 in total

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