Literature DB >> 19615902

Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids.

Vineet Kumar1, Sanjay V Malhotra.   

Abstract

The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.

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Year:  2009        PMID： 19615902     DOI： 10.1016/j.bmcl.2009.06.086

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  19 in total

Review 1.  Selected issues related to the toxicity of ionic liquids and deep eutectic solvents--a review.

Authors:  Błażej Kudłak; Katarzyna Owczarek; Jacek Namieśnik
Journal:  Environ Sci Pollut Res Int       Date:  2015-06-05       Impact factor: 4.223

2.  Crystalline vs. ionic liquid salt forms of active pharmaceutical ingredients: a position paper.

Authors:  Jelena Stoimenovski; Douglas R MacFarlane; Katharina Bica; Robin D Rogers
Journal:  Pharm Res       Date:  2010-02-09       Impact factor: 4.200

3.  Improved Photophysical Properties of Ionic Material-Based Combination Chemo/PDT Nanomedicine.

Authors:  Samantha Macchi; Mohd Zubair; Robert Hill; Nabeel Alwan; Yusuf Khan; Nawab Ali; Grégory Guisbiers; Brian Berry; Noureen Siraj
Journal:  ACS Appl Bio Mater       Date:  2021-09-24

4.  Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance.

Authors:  Kyle J Sommers; Marina E Michaud; Cody E Hogue; Amber M Scharnow; Lauren E Amoo; Ashley A Petersen; Robert G Carden; Kevin P C Minbiole; William M Wuest
Journal:  ACS Infect Dis       Date:  2022-01-25       Impact factor: 5.084

5.  Antiproliferative and antibacterial potential of tetrahexylammonium bromide-based ionic liquids.

Authors:  Roxana Popescu; Marioara Nicoleta Filimon; Daliborca Cristina Vlad; Doina Verdes; Aurica Moatar; Georgiana Moise; Kristine Guran; Ion Valeriu Caraba; Liliana Petculescu Ciochina; Iulia Pinzaru; Cristina Adriana Dehelean; Gabi Dumitrescu
Journal:  Exp Ther Med       Date:  2021-04-23       Impact factor: 2.447

6.  From broad-spectrum biocides to quorum sensing disruptors and mussel repellents: antifouling profile of alkyl triphenylphosphonium salts.

Authors:  Alberto J Martín-Rodríguez; Jose M F Babarro; Fernando Lahoz; Marta Sansón; Víctor S Martín; Manuel Norte; José J Fernández
Journal:  PLoS One       Date:  2015-04-21       Impact factor: 3.240

7.  Tunable Cytotoxicity and Selectivity of Phosphonium Ionic Liquid with Aniline Blue Dye.

Authors:  Samantha Macchi; Mohd Zubair; Nawab Ali; Grégory Guisbiers; Noureen Siraj
Journal:  J Nanosci Nanotechnol       Date:  2021-12-01

8.  The effect of alkyl chain and electronegative atoms in anion on biological activity of anilinium carboxylate bioactive ionic liquids and computational approaches by DFT functional and molecular docking.

Authors:  Ajoy Kumer; Md Wahab Khan
Journal:  Heliyon       Date:  2021-07-08

9.  High Cytotoxic Activity of Phosphonium Salts and Their Complementary Selectivity towards HeLa and K562 Cancer Cells: Identification of Tri-n-butyl-n-hexadecylphosphonium bromide as a Highly Potent Anti-HeLa Phosphonium Salt.

Authors:  Barbara Bachowska; Julia Kazmierczak-Baranska; Marcin Cieslak; Barbara Nawrot; Dorota Szczęsna; Joanna Skalik; Piotr Bałczewski
Journal:  ChemistryOpen       Date:  2012-02-17       Impact factor: 2.911

10.  Novel Nitrobenzazolo[3,2-a]quinolinium Salts Induce Cell Death through a Mechanism Involving DNA Damage, Cell Cycle Changes, and Mitochondrial Permeabilization.

Authors:  Christian Vélez; Osvaldo Cox; Carlos A Rosado-Berrios; Dennise Molina; Luz Arroyo; Sujey Carro; Anton Filikov; Vineet Kumar; Sanjay V Malhotra; Marisol Cordero; Beatriz Zayas
Journal:  Open J Apoptosis       Date:  2013-04-29
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