AIM: To investigate the liver stiffness measurement (LSM) applicability and variability with reference to three probe positions according to the region of liver biopsy. METHODS: The applicability for LSM was defined as at least 10 valid measurements with a success rate greater than 60% and an interquartile range/median LSM < 30%. The LSM variability compared the inter-position concordance and the concordance with FibroTest. RESULTS: Four hundred and forty two consecutive patients were included. The applicability of the anterior position (81%) was significantly higher than that of the reference (69%) and lower positions (68%), (both P = 0.0001). There was a significant difference (0.5 kPa, 95% CI 0.13-0.89; P < 0.0001) between mean LSM estimated at the reference position (9.3 kPa) vs the anterior position (8.8 kPa). Discordance between positions was associated with thoracic fold (P = 0.008). The discordance rate between the reference position result and FibroTest was higher when the 7.1 kPa cutoff was used to define advanced fibrosis instead of 8.8 kPa (33.6% vs 23.5%, P = 0.03). CONCLUSION: The anterior position of the probe should be the first choice for LSM using Fibroscan, as it has a higher applicability without higher variability compared to the usual liver biopsy position.
AIM: To investigate the liver stiffness measurement (LSM) applicability and variability with reference to three probe positions according to the region of liver biopsy. METHODS: The applicability for LSM was defined as at least 10 valid measurements with a success rate greater than 60% and an interquartile range/median LSM < 30%. The LSM variability compared the inter-position concordance and the concordance with FibroTest. RESULTS: Four hundred and forty two consecutive patients were included. The applicability of the anterior position (81%) was significantly higher than that of the reference (69%) and lower positions (68%), (both P = 0.0001). There was a significant difference (0.5 kPa, 95% CI 0.13-0.89; P < 0.0001) between mean LSM estimated at the reference position (9.3 kPa) vs the anterior position (8.8 kPa). Discordance between positions was associated with thoracic fold (P = 0.008). The discordance rate between the reference position result and FibroTest was higher when the 7.1 kPa cutoff was used to define advanced fibrosis instead of 8.8 kPa (33.6% vs 23.5%, P = 0.03). CONCLUSION: The anterior position of the probe should be the first choice for LSM using Fibroscan, as it has a higher applicability without higher variability compared to the usual liver biopsy position.
Authors: Kelly A Gebo; H Franklin Herlong; Michael S Torbenson; Mollie W Jenckes; Geetanjali Chander; Khalil G Ghanem; Samer S El-Kamary; Mark Sulkowski; Eric B Bass Journal: Hepatology Date: 2002-11 Impact factor: 17.425
Authors: J Foucher; E Chanteloup; J Vergniol; L Castéra; B Le Bail; X Adhoute; J Bertet; P Couzigou; V de Lédinghen Journal: Gut Date: 2005-07-14 Impact factor: 23.059
Authors: Chavdar S Pavlov; Giovanni Casazza; Dimitrinka Nikolova; Emmanuel Tsochatzis; Andrew K Burroughs; Vladimir T Ivashkin; Christian Gluud Journal: Cochrane Database Syst Rev Date: 2015-01-22
Authors: P Lutz; J-C Wasmuth; H-D Nischalke; N Vidovic; F Grünhage; F Lammert; J Oldenburg; J K Rockstroh; T Sauerbruch; Ulrich Spengler Journal: Eur J Med Res Date: 2011-08-08 Impact factor: 2.175
Authors: Katharina Hollerieth; Bernhard Gaßmann; Stefan Wagenpfeil; Stephan Kemmner; Uwe Heemann; Konrad Friedrich Stock Journal: Ultrasonography Date: 2017-07-28
Authors: Antonio Rivero-Juárez; Juan Morgaz; Angela Camacho; Pilar Muñoz-Rascón; Juan Manuel Dominguez; Raquel Sánchez-Céspedes; Julián Torre-Cisneros; Antonio Rivero Journal: PLoS One Date: 2012-07-20 Impact factor: 3.240