| Literature DB >> 19609293 |
Dirk Schulz1, Jonny Nachtigall, Julia Riedlinger, Kathrin Schneider, Karl Poralla, Johannes F Imhoff, Winfried Beil, Graeme Nicholson, Hans-Peter Fiedler, Roderich D Süssmuth.
Abstract
Piceamycin, a new macrolactam polyketide antibiotic, was detected by HPLC-diode array screening in extracts of Streptomyces sp. GB 4-2, which was isolated from the mycorrhizosphere of Norway spruce. The structure of piceamycin was determined by mass spectrometry and NMR experiments. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and protein tyrosine phosphatase 1B.Entities:
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Year: 2009 PMID： 19609293 DOI： 10.1038/ja.2009.64
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649