Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications.

Literature DB >> 19609263

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications.

Abstract

New technologies are emerging that utilize artificial microRNA (miRNA) target sites to exploit or inhibit endogenous miRNA regulation. This approach has been used to improve cell-specific targeting for gene and stem cell therapy studies and for animal transgenics, and also to reduce the toxicity of oncolytic viruses and to attenuate viral vaccines. Artificial targets have also been used to sponge or decoy miRNAs as a way to study their functions. This article considers the benefits of this approach and design considerations for future studies.

Entities: Disease

Mesh：

Substances：
MicroRNAs

Year: 2009 PMID： 19609263 DOI： 10.1038/nrg2628

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

67 in total

1. Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line.

Authors: R Constien; A Forde; B Liliensiek; H J Gröne; P Nawroth; G Hämmerling; B Arnold
Journal: Genesis Date: 2001-05 Impact factor: 2.487

Review 2. Emerging role of regulatory T cells in gene transfer.

Authors: Ou Cao; Christian Furlan-Freguia; Valder R Arruda; Roland W Herzog
Journal: Curr Gene Ther Date: 2007-10 Impact factor: 4.391

3. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.

Authors: Fumio Arai; Atsushi Hirao; Masako Ohmura; Hidetaka Sato; Sahoko Matsuoka; Keiyo Takubo; Keisuke Ito; Gou Young Koh; Toshio Suda
Journal: Cell Date: 2004-07-23 Impact factor: 41.582

4. Harnessing endogenous miR-181a to segregate transgenic antigen receptor expression in developing versus post-thymic T cells in murine hematopoietic chimeras.

Authors: Eirini P Papapetrou; Damian Kovalovsky; Laurent Beloeil; Derek Sant'angelo; Michel Sadelain
Journal: J Clin Invest Date: 2008-12-01 Impact factor: 14.808

5. Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs.

Authors: Markus Landthaler; Dimos Gaidatzis; Andrea Rothballer; Po Yu Chen; Steven Joseph Soll; Lana Dinic; Tolulope Ojo; Markus Hafner; Mihaela Zavolan; Thomas Tuschl
Journal: RNA Date: 2008-10-31 Impact factor: 4.942

6. Suppression of non-small cell lung tumor development by the let-7 microRNA family.

Authors: Madhu S Kumar; Stefan J Erkeland; Ryan E Pester; Cindy Y Chen; Margaret S Ebert; Phillip A Sharp; Tyler Jacks
Journal: Proc Natl Acad Sci U S A Date: 2008-02-28 Impact factor: 11.205

7. A mammalian microRNA expression atlas based on small RNA library sequencing.

Authors: Pablo Landgraf; Mirabela Rusu; Robert Sheridan; Alain Sewer; Nicola Iovino; Alexei Aravin; Sébastien Pfeffer; Amanda Rice; Alice O Kamphorst; Markus Landthaler; Carolina Lin; Nicholas D Socci; Leandro Hermida; Valerio Fulci; Sabina Chiaretti; Robin Foà; Julia Schliwka; Uta Fuchs; Astrid Novosel; Roman-Ulrich Müller; Bernhard Schermer; Ute Bissels; Jason Inman; Quang Phan; Minchen Chien; David B Weir; Ruchi Choksi; Gabriella De Vita; Daniela Frezzetti; Hans-Ingo Trompeter; Veit Hornung; Grace Teng; Gunther Hartmann; Miklos Palkovits; Roberto Di Lauro; Peter Wernet; Giuseppe Macino; Charles E Rogler; James W Nagle; Jingyue Ju; F Nina Papavasiliou; Thomas Benzing; Peter Lichter; Wayne Tam; Michael J Brownstein; Andreas Bosio; Arndt Borkhardt; James J Russo; Chris Sander; Mihaela Zavolan; Thomas Tuschl
Journal: Cell Date: 2007-06-29 Impact factor: 41.582

8. Real-time quantification of microRNAs by stem-loop RT-PCR.

Authors: Caifu Chen; Dana A Ridzon; Adam J Broomer; Zhaohui Zhou; Danny H Lee; Julie T Nguyen; Maura Barbisin; Nan Lan Xu; Vikram R Mahuvakar; Mark R Andersen; Kai Qin Lao; Kenneth J Livak; Karl J Guegler
Journal: Nucleic Acids Res Date: 2005-11-27 Impact factor: 16.971

9. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells.

Authors: Michele De Palma; Mary Anna Venneri; Cristina Roca; Luigi Naldini
Journal: Nat Med Date: 2003-05-12 Impact factor: 53.440

Review 10. RNA interference against viruses: strike and counterstrike.

Authors: Joost Haasnoot; Ellen M Westerhout; Ben Berkhout
Journal: Nat Biotechnol Date: 2007-12 Impact factor: 54.908

165 in total

1. A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA.

Authors: Sophie C Cazanave; Justin L Mott; Nafisa A Elmi; Steven F Bronk; Howard C Masuoka; Michael R Charlton; Gregory J Gores
Journal: J Lipid Res Date: 2011-06-01 Impact factor: 5.922

2. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA.

Authors: Lin Zhang; Dongxia Hou; Xi Chen; Donghai Li; Lingyun Zhu; Yujing Zhang; Jing Li; Zhen Bian; Xiangying Liang; Xing Cai; Yuan Yin; Cheng Wang; Tianfu Zhang; Dihan Zhu; Dianmu Zhang; Jie Xu; Qun Chen; Yi Ba; Jing Liu; Qiang Wang; Jianqun Chen; Jin Wang; Meng Wang; Qipeng Zhang; Junfeng Zhang; Ke Zen; Chen-Yu Zhang
Journal: Cell Res Date: 2011-09-20 Impact factor: 25.617

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications.

1. Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line.

Review 2. Emerging role of regulatory T cells in gene transfer.

3. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.

4. Harnessing endogenous miR-181a to segregate transgenic antigen receptor expression in developing versus post-thymic T cells in murine hematopoietic chimeras.

5. Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs.

6. Suppression of non-small cell lung tumor development by the let-7 microRNA family.

7. A mammalian microRNA expression atlas based on small RNA library sequencing.

8. Real-time quantification of microRNAs by stem-loop RT-PCR.

9. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells.

Review 10. RNA interference against viruses: strike and counterstrike.

1. A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA.

2. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA.

Review 3. Hematopoietic stem cell engineering at a crossroads.

Review 4. Studying the mononuclear phagocyte system in the molecular age.

Review 5. Emerging roles of PDGF-D signaling pathway in tumor development and progression.

6. Antagonizing metastasis.

7. MicroRNAs provide powerful postponement.

8. MicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous scleroderma.

9. Massively parallel high-order combinatorial genetics in human cells.

Review 10. MicroRNA and epilepsy: profiling, functions and potential clinical applications.