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Literature DB >> 19603855

Amplifying effect of a release mechanism for fast adaptation in the hair bundle.

Abstract

A "release" mechanism, which has been experimentally observed as the fast component in the hair bundle's response to mechanical stimulation, appears similar to common mechanical relaxation with a damping effect. This observation is puzzling because such a response is expected to have an amplifying role in the mechanoelectrical transduction process in hair cells. Here it is shown that a release mechanism can indeed have a role in amplification, if it is associated with negative stiffness due to the gating of the mechonoelectric transducer channel.

Entities: Disease

Mesh：

Year: 2009 PMID： 19603855 PMCID： PMC2723902 DOI： 10.1121/1.3143782

Source DB: PubMed Journal: J Acoust Soc Am ISSN： 0001-4966 Impact factor: 1.840

13 in total

1. Auditory sensitivity provided by self-tuned critical oscillations of hair cells.

Authors: S Camalet; T Duke; F Jülicher; J Prost
Journal: Proc Natl Acad Sci U S A Date: 2000-03-28 Impact factor: 11.205

2. Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell.

Authors: P Martin; A D Mehta; A J Hudspeth
Journal: Proc Natl Acad Sci U S A Date: 2000-10-24 Impact factor: 11.205

3. Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog.

Authors: D Bozovic; A J Hudspeth
Journal: Proc Natl Acad Sci U S A Date: 2003-01-21 Impact factor: 11.205

Review 4. Hair-cell mechanotransduction and cochlear amplification.

Authors: Meredith LeMasurier; Peter G Gillespie
Journal: Neuron Date: 2005-11-03 Impact factor: 17.173

Review 5. Active hair bundle movements in auditory hair cells.

Authors: Robert Fettiplace
Journal: J Physiol Date: 2006-08-03 Impact factor: 5.182

6. Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cell.

Authors: J Howard; A J Hudspeth
Journal: Neuron Date: 1988-05 Impact factor: 17.173

Amplifying effect of a release mechanism for fast adaptation in the hair bundle.

1. Auditory sensitivity provided by self-tuned critical oscillations of hair cells.

2. Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell.

3. Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog.

Review 4. Hair-cell mechanotransduction and cochlear amplification.

Review 5. Active hair bundle movements in auditory hair cells.

6. Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cell.

7. Identification of a 120 kd hair-bundle myosin located near stereociliary tips.

8. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

9. Fast adaptation in vestibular hair cells requires myosin-1c activity.

10. Spontaneous oscillation by hair bundles of the bullfrog's sacculus.

1. Anomalous Brownian motion discloses viscoelasticity in the ear's mechanoelectrical-transduction apparatus.

2. Gating of two mechanoelectrical transducer channels associated with a single tip link.

3. Power dissipation in the subtectorial space of the mammalian cochlea is modulated by inner hair cell stereocilia.