| Literature DB >> 19603112 |
Maria Fairbank1, Pascal St-Pierre, Ivan R Nabi.
Abstract
Phosphoglucose isomerase (PGI) is a glycolytic enzyme that exhibits a dual function as an extracellular cytokine, under the name autocrine motility factor (AMF). Its cell surface receptor, gp78/AMFR, is also localized to the endoplasmic reticulum where it functions as an E3 ubiquitin ligase. Expression of both AMF/PGI and gp78/AMFR is associated with cancer and, in this review, we will discuss various aspects of the biology of this ligand-receptor complex and its role in tumor progression.Entities:
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Year: 2009 PMID: 19603112 DOI: 10.1039/b820820b
Source DB: PubMed Journal: Mol Biosyst ISSN: 1742-2051