BACKGROUND: Whether echo-Doppler-derived index of ventricular elastance or ventriculoarterial interaction can reliably reflect circulatory efficiency in various conditions was investigated in the present study and whether they can be helpful in predicting exercise capacity in patients with dilated cardiomyopathy (DCM). METHODS AND RESULTS: The 25 patients with DCM, 25 age- and gender-matched hypertensive patients, and 25 marathon runners underwent symptom-limited graded supine bicycle exercise echocardiography after resting echo-Doppler evaluation. Echo-Doppler-derived left ventricular (LV) diastolic elastance index (Ed), ventricular-vascular coupling index (10 x Ea/Ees), based on arterial elastance index (Ea) to LV end-systolic elastance index (Ees), and hemodynamic parameters were measured during rest and exercise. DCM patients had lower Ees, higher Ed and Ea/Ees with blunted exercise responses of Ees than the other groups, and the hypertensive patients had lower Ees and DeltaEes compared with the marathon runners. Resting Ed, Ea/Ees, and total stiffness index (10 x Ed x Ea/Ees) correlated with exercise duration independent of age and gender. A stiffness index of 0.8 could reliably predict impaired exercise capacity. CONCLUSIONS: Echo-derived elastance is predictive of exercise capacity in patients with DCM.
BACKGROUND: Whether echo-Doppler-derived index of ventricular elastance or ventriculoarterial interaction can reliably reflect circulatory efficiency in various conditions was investigated in the present study and whether they can be helpful in predicting exercise capacity in patients with dilated cardiomyopathy (DCM). METHODS AND RESULTS: The 25 patients with DCM, 25 age- and gender-matched hypertensivepatients, and 25 marathon runners underwent symptom-limited graded supine bicycle exercise echocardiography after resting echo-Doppler evaluation. Echo-Doppler-derived left ventricular (LV) diastolic elastance index (Ed), ventricular-vascular coupling index (10 x Ea/Ees), based on arterial elastance index (Ea) to LV end-systolic elastance index (Ees), and hemodynamic parameters were measured during rest and exercise. DCMpatients had lower Ees, higher Ed and Ea/Ees with blunted exercise responses of Ees than the other groups, and the hypertensivepatients had lower Ees and DeltaEes compared with the marathon runners. Resting Ed, Ea/Ees, and total stiffness index (10 x Ed x Ea/Ees) correlated with exercise duration independent of age and gender. A stiffness index of 0.8 could reliably predict impaired exercise capacity. CONCLUSIONS: Echo-derived elastance is predictive of exercise capacity in patients with DCM.
Authors: Hyemoon Chung; Sung Wan Kim; Hyung Oh Kim; Jung Myung Lee; Jong Shin Woo; Jin Bae Kim; Soo Joong Kim; Weon Kim; Kwon Sam Kim; Woo-Shik Kim Journal: Int J Heart Fail Date: 2020-06-02
Authors: Francesco Antonini-Canterin; Stefano Poli; Olga Vriz; Daniela Pavan; Vitantonio Di Bello; Gian Luigi Nicolosi Journal: J Cardiovasc Echogr Date: 2013 Oct-Dec
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