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Literature DB >> 19597620

A DNA-binding Gd chelate for the detection of cell death by MRI.

Elisabeth Garanger¹, Scott A Hilderbrand, Joseph T Blois, David E Sosnovik, Ralph Weissleder, Lee Josephson.

Abstract

GadoTO, a MR contrast agent for the detection of cell death, consists of a nucleic acid-binding fluorophore attached to a gadolinium chelate.

Entities: CellLine Chemical Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 19597620 PMCID： PMC2754278 DOI： 10.1039/b907375b

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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2. The slow cell death response when screening chemotherapeutic agents.

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3. Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium.

Authors: Shuning Huang; Howard H Chen; Hushan Yuan; Guangping Dai; Daniel T Schuhle; Choukri Mekkaoui; Soeun Ngoy; Ronglih Liao; Peter Caravan; Lee Josephson; David E Sosnovik
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4. Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems.

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